scholarly journals Preparation of factor IX deficient human plasma by immunoaffinity chromatography using a monoclonal antibody

Blood ◽  
1982 ◽  
Vol 59 (3) ◽  
pp. 664-670 ◽  
Author(s):  
AH Goodall ◽  
G Kemble ◽  
DP O'Brien ◽  
E Rawlings ◽  
F Rotblat ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Human Plasma ◽  
Large Scale ◽  
High Capacity ◽  
Factor Ix ◽  
Affinity Column ◽  
Scale Production ◽  
Large Scale Production ◽  
Normal Human ◽  
Coagulation Assay

Abstract A murine hybridoma clone is described that grows continuously in culture and produces a monoclonal antibody we have called Royal Free Monoclonal Antibody to factor IX No. 1 (RFF-IX/1). This has high affinity for a coagulation site on factor IX. RFF-IX/1 immobilised on sepharose can be used to deplete factor IX from normal human plasma. This immunoaffinity depleted plasma is indistinguishable from severe Christmas disease plasma and can be used as the substrate in a one stage coagulation assay for factor IX. The affinity column has high capacity and can be regenerated so that large scale production from normal plasma of factor IX deficient plasma as a diagnostic reagent is now feasible.

scholarly journals Preparation of factor IX deficient human plasma by immunoaffinity chromatography using a monoclonal antibody

Blood ◽  
1982 ◽  
Vol 59 (3) ◽  
pp. 664-670
Author(s):  
AH Goodall ◽  
G Kemble ◽  
DP O'Brien ◽  
E Rawlings ◽  
F Rotblat ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Human Plasma ◽  
Large Scale ◽  
High Capacity ◽  
Factor Ix ◽  
Affinity Column ◽  
Scale Production ◽  
Large Scale Production ◽  
Normal Human ◽  
Coagulation Assay

A murine hybridoma clone is described that grows continuously in culture and produces a monoclonal antibody we have called Royal Free Monoclonal Antibody to factor IX No. 1 (RFF-IX/1). This has high affinity for a coagulation site on factor IX. RFF-IX/1 immobilised on sepharose can be used to deplete factor IX from normal human plasma. This immunoaffinity depleted plasma is indistinguishable from severe Christmas disease plasma and can be used as the substrate in a one stage coagulation assay for factor IX. The affinity column has high capacity and can be regenerated so that large scale production from normal plasma of factor IX deficient plasma as a diagnostic reagent is now feasible.

Large-Scale Production and Properties of a Solvent-Detergent-Treated Factor IX Concentrate from Human Plasma

Vox Sanguinis ◽  
1988 ◽  
Vol 55 (4) ◽  
pp. 202-210 ◽  
Author(s):  
C. Michalski ◽  
F. Bal ◽  
T. Burnouf ◽  
M. Goudemand
Keyword(s):  
Human Plasma ◽  
Large Scale ◽  
Factor Ix ◽  
Scale Production ◽  
Large Scale Production

Silicon/graphene based nanocomposite anode: large-scale production and stable high capacity for lithium ion batteries

2014 ◽  
Vol 2 (24) ◽  
pp. 9118-9125 ◽  
Author(s):  
Renzong Hu ◽  
Wei Sun ◽  
Yulong Chen ◽  
Meiqin Zeng ◽  
Min Zhu
Keyword(s):  
Lithium Ion Batteries ◽  
Large Scale ◽  
High Capacity ◽  
Lithium Ion ◽  
Scale Production ◽  
Large Scale Production ◽  
Graphene Nanocomposite

Plasma-assisted milled Si/graphene nanocomposite anode delivers high capacity and good cycleability in half and full cells using a LiMn2O4 cathode.

scholarly journals The Hunt for Compact Power

2000 ◽  
Vol 122 (04) ◽  
pp. 42-45
Author(s):  
Paul Sharke
Keyword(s):  
Large Scale ◽  
Superconducting Magnets ◽  
High Capacity ◽  
Scale Production ◽  
Developmental Phase ◽  
Dc Distribution ◽  
Large Scale Production ◽  
Superconducting Coils ◽  
The Magnetic Field ◽  
Main Factor

This article explains features of a ship propulsion motor with superconducting coils that hushes machinery noise and hollows out confined engine rooms. American Superconductor Corp. of Westborough, MA, announced plans to build a high-capacity manufacturing plant for its superconducting wire. This will move the company’s high temperature superconductor (HTS), wire from a developmental phase into large-scale production. IPS is exploring more than just propulsion motor technology. Engineers are evaluating the entire shipboard electrical system, from ship’s service power, to dc distribution, to power electronics—as well as the propulsion motor itself. The Navy, having decided upon electric drive for its next warship, has left the door open for superconducting motors. Superconducting motors can develop the same torque and horsepower within a motor frame that is nearly a third the size of a comparably rated conventional motor. The main factor leading to an HTS motor’s smaller size for a given horsepower output is the magnetic field strength that superconducting magnets create. Iron teeth, used to enhance magnetic flux in conventional rotors and stators, are not needed by superconducting motors.

Insoluble human plasma protein immunoadsorbents. Large-scale production and storage

1977 ◽  
Vol 74 (3) ◽  
pp. 237-245 ◽  
Author(s):  
Samuel T. Nerenberg ◽  
Rameshwar Prasad ◽  
Nancy Biskup ◽  
Linda Pedersen (Demarco)
Keyword(s):  
Human Plasma ◽  
Plasma Protein ◽  
Large Scale ◽  
Scale Production ◽  
Human Plasma Protein ◽  
Large Scale Production ◽  
And Storage

Large-scale production and properties of human plasma-derived activated Factor VII concentrate

Vox Sanguinis ◽  
2003 ◽  
Vol 84 (1) ◽  
pp. 54-64 ◽  
Author(s):  
K. Tomokiyo ◽  
H. Yano ◽  
M. Imamura ◽  
Y. Nakano ◽  
T. Nakagaki ◽  
...  
Keyword(s):  
Human Plasma ◽  
Large Scale ◽  
Factor Vii ◽  
Scale Production ◽  
Activated Factor Vii ◽  
Large Scale Production

Large Scale Production of Human Plasma Fractions

Vox Sanguinis ◽  
1962 ◽  
Vol 7 (4) ◽  
pp. 414-424 ◽  
Author(s):  
P. Kistler ◽  
Hs. Nitschmann
Keyword(s):  
Human Plasma ◽  
Large Scale ◽  
Scale Production ◽  
Large Scale Production ◽  
Plasma Fractions
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