Neural crest cell migration in relation to extracellular matrix organization in the embryonic axolotl trunk

1980 ◽  
Vol 75 (1) ◽  
pp. 148-167 ◽  
Author(s):  
Jan Löfberg ◽  
Kerstin Ahlfors ◽  
Charlotte Fällström
Keyword(s):  
Extracellular Matrix ◽  
Cell Migration ◽  
Neural Crest ◽  
Neural Crest Cell ◽  
Neural Crest Cell Migration ◽  
Matrix Organization ◽  
Crest Cell

Role of the Extracellular Matrix in Neural Crest Cell Migration

1984 ◽  
pp. 139-144 ◽  
Author(s):  
Jean Paul Thiery ◽  
Roberto Rovasio ◽  
Annie Delouvée ◽  
Michel Vincent ◽  
Jean Loup Duband ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Migration ◽  
Neural Crest ◽  
Neural Crest Cell ◽  
Neural Crest Cell Migration ◽  
Crest Cell

Evidence for extracellular matrix stimulation of neural crest cell migration

1983 ◽  
Vol 41 ◽  
pp. 520-521
Author(s):  
L. Jönsson ◽  
J. Löfberg ◽  
Anita Nynäs Mccoy
Keyword(s):  
Extracellular Matrix ◽  
Cell Migration ◽  
Neural Crest ◽  
Neural Crest Cell ◽  
Ambystoma Mexicanum ◽  
Extrinsic Factors ◽  
Anterior Trunk ◽  
Neural Crest Cell Migration ◽  
Crest Cell ◽  
Stimulation Of

The purpose of this experiment was to study if extrinsic factors regulate initial neural crest cell migration. Recent experiments suggest that a crucial extrinsic factor may be the embryonic extracellular matrix (ECM).The initiation of neural crest cell migration begins in the anterior trunk segments and follows gradually in more posterior ones. If the surrounding ECM has a migration-stimulating capacity, one would expect a decrease in the amount of ECM anterior-posteriorly at the initial migration stage.Epidermal grafts from the 3rd trunk somite level of Stage 25 axolotl embryos (Ambystoma mexicanum) were transplanted to the 9th trunk somite level of Stage 25 embryos (Fig. 1). At Stage 25, initial migration is soon to begin at the 3rd trunk somite level. In the controls, epidermal grafts were transplanted between the 9th trunk somite levels of Stage 25 embryos. The operated embryos were incubated for 48 hr at 15°C, fixed and prepared for light microscopy studies.

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