Link the degree of progression of motor and cognitive impairment in Parkinson’s disease and parameters of cognitive evoked potentials brain activity recognized not always unambiguous. This is due to the wide range of differences in amplitude and latency time of evoked potentials in the different leads of electroencephalogram caused functional reorganization of neuronal activity in brain structures in the early stages of the disease. Objective. The aim is to determine the correlation of the cognitive auditory evoked potentials P300 characteristics and symptom features in patients with Parkinson’s disease. Methods. The study involved 60 people, right-handers: 34 people (24 women and 10 men) with a verified diagnosis of Parkinson’s disease and the control group — 26 people (20 women and 6 men). The disease duration, severity of symptoms (Unified Parkinson’s Disease Rating Scale), and stage of the disease (Hoehn, Yahr) were determined, the 15-item Geriatric Depression Scale was used to indicate the depression symptoms. Assessment of the electroencephalogram and auditory evoked potentials P300 was performed by an electroencephalograph «Encephalan» (Medicom, Taganrog, Russia). The minimum amplitude and the maximum latency of P300 in electroencephalogram-leads (F3, F4, C3, C4, P3, P4, F7, F8, T3, T4, T5 and T6) on the right and left sides were determined. Results. A significant positive correlation between the amplitude of evoked potential P300 on the left and duration of Parkinson’s disease was revealed, moreover the severity of disease symptoms such as left-side resting tremors of the hand, left-side muscle tension of the hand and/or foot, rising from a chair without using their hands, posture disorder were established. Conclusion. Marked brain asymmetry in the form of increase of the P300 amplitude on the left side combined with a significant reduction in the P300 amplitude on the right side in contra lateral electroencephalogram-lead indicates unfavorable prognosis in relation to cognitive dysfunction and motor disorders identified with left-sided Parkinson’s disease onset.
The Predictability of Motor and Cognitive Impairment According to Brain Asymmetry of Cognitive Evoked Potentials P300 and Features of Symptom Complex in Patients with Parkinson’s Disease
