GraphAttack

Graph structures are a natural representation of important and pervasive data. While graph applications have significant parallelism, their characteristic pointer indirect loads to neighbor data hinder scalability to large datasets on multicore systems. A scalable and efficient system must tolerate latency while leveraging data parallelism across millions of vertices. Modern Out-of-Order (OoO) cores inherently tolerate a fraction of long latencies, but become clogged when running severely memory-bound applications. Combined with large power/area footprints, this limits their parallel scaling potential and, consequently, the gains that existing software frameworks can achieve. Conversely, accelerator and memory hierarchy designs provide performant hardware specializations, but cannot support diverse application demands. To address these shortcomings, we present GraphAttack, a hardware-software data supply approach that accelerates graph applications on in-order multicore architectures. GraphAttack proposes compiler passes to (1) identify idiomatic long-latency loads and (2) slice programs along these loads into data Producer/ Consumer threads to map onto pairs of parallel cores. Each pair shares a communication queue; the Producer asynchronously issues long-latency loads, whose results are buffered in the queue and used by the Consumer. This scheme drastically increases memory-level parallelism (MLP) to mitigate latency bottlenecks. In equal-area comparisons, GraphAttack outperforms OoO cores, do-all parallelism, prefetching, and prior decoupling approaches, achieving a 2.87× speedup and 8.61× gain in energy efficiency across a range of graph applications. These improvements scale; GraphAttack achieves a 3× speedup over 64 parallel cores. Lastly, it has pragmatic design principles; it enhances in-order architectures that are gaining increasing open-source support.

Features of use of evoked potential method on children with epilepsy of pre- and puberty age-old period

This paper of the usage of the evoked potential method is studied, in patients with epilepsy. A brief description of the method is described. A pilot study of auditory long-latency and visual on the outbreak of evoked potential was carried out in 19 children with various forms of epilepsy, who are in long-term remission, and also with pharmacoresistant seizures. It was found that the visual evoked potentials are more indicative than auditory evoked potential. In most cases, a decrease in the amplitude and lengthening of evoked potentials latencies was revealed. Moreover, in the presence of focal changes, interocular or interaural differences were recorded. In that way, it is necessary to study the features of evoked potentials in children with epilepsy, study evoked potentials in the course of treatment in order to predict the course of the disease and the effectiveness of the therapy. The obtained data will serve as the basis for further research of the evoked potential method in children with epilepsy.

Concurrent cytologic and colposcopic evaluation of symptomatic cervical erosion

Background: Cervical cancer is amongst the leading causes of deaths due to cancer in developing countries. Moreover, preinvasive lesions of the cervix have a long latency period for conversion into malignancy and are also detectable by screening techniques. Hence, colposcopy in addition to cytology should be carried out wherever facility is available to ensure early detection and timely management.Methods: Simultaneous cytology and colposcopy was done for 80 women with symptomatic cervical erosion followed by a colposcopic directed biopsy in women with MRCI >3. Finally, correlation between cytology, colposcopy and histopathological results was done.Results: 65/80 women were biopsied. 12/80 women had MRCI >6 amongst which 10/80 were confirmed to have a high grade lesion on histopathology. 13/80 had lesser abnormalities (ASCUS and LSIL) amongst which 3/80 had CIN1 on histopathology. Only 2/80 had HSIL on cytology as compared to 8/80 on histopathology that had CIN 2/3. Lastly, only 1/80 had SCC on cytology compared to 2/80 on histopathology. The sensitivity, specificity, PPV and NPV of cytology and colposcopy for diagnosing cervical dysplasia was 46.1%, 83.5%, 35.2%, 88.8% and 84.6%, 86.5%, 55%, 96.6% respectively making colposcopy a better screening tool than cytology for evaluating cervical malignancy.Conclusions: Colposcopic examination should ideally be carried out in all women with symptomatic cervical erosion in addition to cytology. Moreover, suspicious areas should be biopsied even if cytology is normal to exclude malignancy.

Going Beyond Rote Auditory Learning: Neural Patterns of Generalized Auditory Learning

The ability to generalize across specific experiences is vital for the recognition of new patterns, especially in speech perception considering acoustic–phonetic pattern variability. Indeed, behavioral research has demonstrated that listeners are able via a process of generalized learning to leverage their experiences of past words said by difficult-to-understand talker to improve their understanding for new words said by that talker. Here, we examine differences in neural responses to generalized versus rote learning in auditory cortical processing by training listeners to understand a novel synthetic talker. Using a pretest–posttest design with EEG, participants were trained using either (1) a large inventory of words where no words were repeated across the experiment (generalized learning) or (2) a small inventory of words where words were repeated (rote learning). Analysis of long-latency auditory evoked potentials at pretest and posttest revealed that rote and generalized learning both produced rapid changes in auditory processing, yet the nature of these changes differed. Generalized learning was marked by an amplitude reduction in the N1–P2 complex and by the presence of a late negativity wave in the auditory evoked potential following training; rote learning was marked only by temporally later scalp topography differences. The early N1–P2 change, found only for generalized learning, is consistent with an active processing account of speech perception, which proposes that the ability to rapidly adjust to the specific vocal characteristics of a new talker (for which rote learning is rare) relies on attentional mechanisms to selectively modify early auditory processing sensitivity.

The distribution and reliability of TMS-evoked short- and long-latency afferent interactions

Short-latency afferent inhibition (SAI) and long-latency afferent inhibition (LAI) occur when the motor evoked potential (MEP) elicited by transcranial magnetic stimulation (TMS) is reduced by the delivery of a preceding peripheral nerve stimulus. The intra-individual variability in SAI and LAI is considerable, and the influence of sample demographics (e.g., age and biological sex) and testing context (e.g., time of day) is not clear. There are also no established normative values for these measures, and their reliability varies from study-to-study. To address these issues and facilitate the interpretation of SAI and LAI research, we pooled data from studies published by our lab between 2014 and 2020 and performed several retrospective analyses. Patterns in the depth of inhibition with respect to age, biological sex and time of testing were investigated, and the relative reliability of measurements from studies with repeated baseline SAI and LAI assessments was examined. Normative SAI and LAI values with respect to the mean and standard deviation were also calculated. Our data show no relationship between the depth of inhibition for SAI and LAI with either time of day or age. Further, there was no significant difference in SAI or LAI between males and females. Intra-class correlation coefficients (ICC) for repeated measurements of SAI and LAI ranged from moderate (ICC = 0.526) to strong (ICC = 0.881). The mean value of SAI was 0.71 ± 0.27 and the mean value of LAI was 0.61 ± 0.34. This retrospective study provides normative values, reliability estimates, and an exploration of demographic and testing influences on these measures as assessed in our lab. To further facilitate the interpretation of SAI and LAI data, similar studies should be performed by other labs that use these measures.

Metastatic Clear Renal-Cell Carcinoma Mimicking Anaplastic Thyroid Cancer: A Case Report

Metastatic renal cell carcinoma to the thyroid is a rare yet aggressive histopathologic diagnosis, which may often be omitted from the initial clinical differential. This is in part due to the long latency period between the initial renal primary and appearance of metastatic disease, coupled with the diagnostic limitations of fine-needle aspiration biopsies. We herein present an interesting case of a metastatic clear-cell renal-cell carcinoma mimicking an aggressive primary thyroid neoplasm, 10 years after a nephrectomy for a renal primary, highlighting key diagnostic and management considerations.

The role of fixation disengagement and oculomotor preparation in gap saccade task is gap-duration dependent

The influence of internal brain state on behavioral performance is well illustrated by the gap-saccade task, in which saccades might be initiated with short latency (express saccade) or with long latency (regular saccade) even though the external visual condition is identical. Accumulated evidence has demonstrated that the internal brain state is different before the initiation of an express saccade than of a regular saccade. However, the reported origin of the fluctuation of internal brain state is disputed among previous studies, e.g., the fixation disengagement theory versus the oculomotor preparation theory. In the present study, we examined these two theories by analyzing the rate and direction of fixational saccades, i.e., small amplitude saccades during fixation period, because they could be modulated by internal brain state. Since fixation disengagement is not spatially tuned, it might affect the rate but not direction of fixational saccade. In contrast, oculomotor preparation can contain the spatial information for upcoming saccade, thus, it might have a distinct effect on fixational saccade direction. We found that the different spatiotemporal characteristics of fixational saccades among tasks with different gap durations reveals different driven force to change the internal brain state. Under short gap duration (100 ms), fixation disengagement plays a primary role in switching internal brain state. Conversely, under medium (200 ms) and long (400 ms) gap durations, oculomotor preparation plays a primary role. These results suggest that both fixation disengagement and oculomotor preparation can change the internal brain state, but their relative contributions are gap-duration dependent.