Relationship between the positive inotropic effect of ouabain and its inhibitory effects on Na+, K+-ATPase and active transport of Rb+ in the dog heart

1981 ◽  
Vol 70 (3) ◽  
pp. 273-278 ◽  
Author(s):  
Hee M. Rhee ◽  
Wu-Hsiung Huang ◽  
Amir Askari
Keyword(s):  
Active Transport ◽  
Positive Inotropic Effect ◽  
Inotropic Effect ◽  
Inhibitory Effects ◽  
Dog Heart

Positive Inotropic Effect of Felodipine in Isovolumically Beating Dog Heart

1986 ◽  
Vol 70 (s13) ◽  
pp. 7P-7P
Author(s):  
K. Petterson ◽  
M.I.M. Noble ◽  
J-A. Bjorkman ◽  
J. Hynd ◽  
A.J. Drake-Holland
Keyword(s):  
Positive Inotropic Effect ◽  
Inotropic Effect ◽  
Dog Heart

Positive inotropic effect of felodipine in the isovolumic dog heart

1985 ◽  
Vol 17 ◽  
pp. 46-46
Author(s):  
K PETTERSSON ◽  
A DRAKEHOLLAND ◽  
M NOBLE ◽  
J BJORKMAN ◽  
J HYND
Keyword(s):  
Positive Inotropic Effect ◽  
Inotropic Effect ◽  
Dog Heart

The Positive Inotropic Effect of Felodipine in Isovolumically Beating Dog Heart

1987 ◽  
Vol 10 ◽  
pp. S112-S118 ◽  
Author(s):  
Knut Pettersson ◽  
Mark I. M. Noble ◽  
Jan-Arne Björkman ◽  
John Hynd ◽  
Angela J. Drake-Holland
Keyword(s):  
Positive Inotropic Effect ◽  
Inotropic Effect ◽  
Dog Heart

scholarly journals Enhanced G i Signaling Selectively Negates β 2 -Adrenergic Receptor (AR)– but Not β 1 -AR–Mediated Positive Inotropic Effect in Myocytes From Failing Rat Hearts

Circulation ◽  
2003 ◽  
Vol 108 (13) ◽  
pp. 1633-1639 ◽  
Author(s):  
Rui-Ping Xiao ◽  
Sheng-Jun Zhang ◽  
Khalid Chakir ◽  
Pavel Avdonin ◽  
Weizhong Zhu ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Positive Inotropic Effect ◽  
Inotropic Effect ◽  
Rat Hearts

Somatostatin modulates cholinergic neurotransmission in canine antral muscle

1988 ◽  
Vol 254 (2) ◽  
pp. G201-G209 ◽  
Author(s):  
C. B. Koelbel ◽  
G. van Deventer ◽  
S. Khawaja ◽  
M. Mogard ◽  
J. H. Walsh ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Substance P ◽  
Prostaglandin E2 ◽  
Positive Inotropic Effect ◽  
Mechanical Response ◽  
Inhibitory Effect ◽  
Inotropic Effect ◽  
Inotropic Response ◽  
Cholinergic Neurotransmission

Somatostatin has been shown to inhibit antral motility in vivo. To examine the effect of somatostatin on cholinergic neurotransmission in the canine antrum, we studied the mechanical response of and the release of [3H]acetylcholine from canine longitudinal antral muscle in response to substance P, gastrin 17, and electrical stimulation. In unstimulated tissues, somatostatin had a positive inotropic effect on spontaneous phasic contractions. In tissues stimulated with substance P and gastrin 17, but not with electrical stimulation, somatostatin inhibited the phasic inotropic response dose dependently. This inhibitory effect was abolished by indomethacin. Somatostatin stimulated the release of prostaglandin E2 radioimmunoreactivity, and prostaglandin E2 inhibited the release of [3H]acetylcholine induced by substance P and electrical stimulation. Somatostatin increased the release of [3H]acetylcholine from unstimulated tissues by a tetrodotoxin-sensitive mechanism but inhibited the release induced by substance P and electrical stimulation. These results suggest that somatostatin has a dual modulatory effect on cholinergic neurotransmission in canine longitudinal antral muscle. This effect is excitatory in unstimulated tissues and inhibitory in stimulated tissues. The inhibitory effect is partially mediated by prostaglandins.

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