In vivo dopamine receptor agonist binding in rat brain: Relation with pharmacological effects

1983 ◽  
Vol 90 (4) ◽  
pp. 433-436 ◽  
Author(s):  
Matthijs G.P. Feenstra ◽  
Hans Rollema ◽  
Theo B.A. Mulder ◽  
Jan B. De Vries ◽  
Alan S. Horn
Keyword(s):  
Rat Brain ◽  
Dopamine Receptor ◽  
Receptor Agonist ◽  
Dopamine Receptor Agonist ◽  
Pharmacological Effects ◽  
Agonist Binding

N-0437:a selective D-2 dopamine receptor agonist in in vitro and in vivo models

1988 ◽  
Vol 147 (2) ◽  
pp. 249-258 ◽  
Author(s):  
Jan Van der Weide ◽  
Jan B. De Vries ◽  
Pieter G. Tepper ◽  
Diana N. Krause ◽  
Margarita L. Dubocovich ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Receptor Agonist ◽  
Dopamine Receptor Agonist ◽  
In Vivo Models

scholarly journals Effects of costimulation of dopamine D1- and D2-like receptors on renal function

1998 ◽  
Vol 275 (4) ◽  
pp. R986-R994 ◽  
Author(s):  
Pedro A. Jose ◽  
Laureano D. Asico ◽  
Gilbert M. Eisner ◽  
Felice Pocchiari ◽  
Claudio Semeraro ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Sodium Transport ◽  
Sodium Excretion ◽  
Rank Order ◽  
Sch 23390 ◽  
Urine Flow ◽  
Dopamine Receptor Agonist ◽  
Vasodilatory Effect

In vitro studies have suggested that dopamine D1- and D2-like receptors interact to inhibit renal sodium transport. We used Z-1046, a dopamine receptor agonist with the rank-order potency D3 ≥ D4 > D2 > D5 > D1, to test the hypothesis that D1- and D2-like receptors interact to inhibit renal sodium transport in vivo in anesthetized rats. Increasing doses of Z-1046, administered via the right renal artery, increased renal blood flow (RBF), urine flow, and absolute and fractional sodium excretion without affecting glomerular filtration rate. For determination of the dopamine receptor involved in the renal functional effects of Z-1046, another group of rats received Z-1046 at 2 μg ⋅ kg−1 ⋅ min−1( n = 10) in the presence or absence of the D2-like receptor antagonist domperidone and/or the D1-like antagonist SCH-23390. Domperidone alone had no effect but blocked the Z-1046-mediated increase in urine flow and sodium excretion; it enhanced the increase in RBF after Z-1046. SCH-23390 by itself decreased urine flow and sodium excretion without affecting RBF and blocked the diuretic, natriuretic, and renal vasodilatory effect of Z-1046. We conclude that the renal vasodilatory effect of Z-1046 is D1-like receptor dependent, whereas the diuretic and natriuretic effects are both D1- and D2-like receptor dependent.

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