Modulation by hydroxyeicosatetraenoic acids (HETEs) of arachidonic acid metabolism in mouse resident peritoneal macrophages

1985 ◽  
Vol 107 (2) ◽  
pp. 215-222 ◽  
Author(s):  
Joseph Chang ◽  
Barbara Lamb ◽  
Laura Marinari ◽  
Anthony F. Kreft ◽  
Alan J. Lewis
Author(s):  
Elisa Domi ◽  
Malvina Hoxha ◽  
Bianka Hoxha ◽  
Bruno Zappacosta

Purpose: Hyperhomocysteinemia (HHcy) has been considered a risk factor for different diseases including cardiovascular disease (CVD), inflammation, neurological diseases, cancer and many other pathological conditions. Likewise, arachidonic acid (AA) metabolism is implicated in both vascular homeostasis and inflammation as shown by the development of CVD following the imbalance of its metabolites. Aim of The Review: This review summarizes how homocysteine (Hcy) can influence the metabolism of AA. Methods: In silico literature searches were performed on PubMed and Scopus as main sources. Results: Several studies have shown that altered levels of Hcy, through AA release and metabolism, can influence the synthesis and the activity of prostaglandins (PGs), prostacyclin (PGI₂), thromboxane (TXA), epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs). Conclusions: We believe that by targeting Hcy in AA pathways, novel compounds with better pharmacological and pharmacodynamics benefits may be obtained and that this information is valuable for dietician to manipulate diets to improve health.


Author(s):  
Kazuo Ohuchi ◽  
Masako Watanabe ◽  
Noriyasu Hirasawa ◽  
Susumu Tsurufuji ◽  
Tsuneo Ozeki ◽  
...  

1989 ◽  
Vol 45 (5) ◽  
pp. 466-473 ◽  
Author(s):  
Wim Engels ◽  
Gert Grauls ◽  
Paul J. Lemmens ◽  
Wil J. Mullers ◽  
Cathrien A. Bruggeman

Author(s):  
Masako Watanabe ◽  
Toshiya Tamura ◽  
Mariko Ohashi ◽  
Noriyasu Hirasawa ◽  
Tsuneo Ozeki ◽  
...  

1988 ◽  
Vol 94 (3) ◽  
pp. 917-923 ◽  
Author(s):  
Kazuo Ohuchi ◽  
Tadaki Sugawara ◽  
Masako Watanabe ◽  
Noriyasu Hirasawa ◽  
Susumu Tsurufuji ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document