Platelet activating factor interaction with tumor necrosis factor and myocardial depressant factor in splanchnic artery occlusion shock

1992 ◽  
Vol 222 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Basilia Zingarelli ◽  
Francesco Squadrito ◽  
Mariapatrizia Ioculano ◽  
Domenica Altavilla ◽  
Federico Bussolino ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Platelet Activating Factor ◽  
Artery Occlusion ◽  
Myocardial Depressant Factor ◽  
Splanchnic Artery ◽  
Factor Interaction ◽  
Necrosis Factor

Tacrolimus (FK506) reduces Tumor Necrosis Factor and protects against splanchnic artery occlusion shock.

Shock ◽  
1998 ◽  
Vol 9 (Supplement) ◽  
pp. 16
Author(s):  
F. Squadrito ◽  
D. Altavilla ◽  
G. Squadrito ◽  
G. M. Campo ◽  
M Ferlito ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Artery Occlusion ◽  
Splanchnic Artery ◽  
Necrosis Factor

Tumor necrosis factor induces E-selectin production in splanchnic artery occlusion shock

1995 ◽  
Vol 268 (4) ◽  
pp. H1412-H1417 ◽  
Author(s):  
D. Altavilla ◽  
F. Squadrito ◽  
P. Canale ◽  
M. Ioculano ◽  
G. M. Campo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Tumor Necrosis Factor ◽  
Survival Time ◽  
Tumor Necrosis ◽  
Serum Levels ◽  
Artery Occlusion ◽  
Tnf Alpha ◽  
Arterial Blood ◽  
Splanchnic Artery ◽  
Necrosis Factor

Splanchnic arteries were clamped for 45 min to induce splanchnic artery occlusion (SAO) shock in anesthetized rats. Sham-operated animals were used as controls. Survival time, serum tumor necrosis factor-alpha (TNF-alpha), white blood cell (WBC) count, mean arterial blood pressure, myeloperoxidase (MPO) activity, and serum levels of soluble E-selectin (sE-selectin) were investigated. SAO-shocked rats exhibited decreased survival time (95 +/- 11 min, whereas sham-shocked rats survived for > 5 h), reduced mean arterial blood pressure, increased serum levels of TNF-alpha (185 +/- 8 U/ml) and MPO activity in the ileum (0.11 +/- 0.03 U x 10(-3)/g tissue) and lung (1.5 +/- 0.4 U x 10(-3)/g tissue), leukopenia, and enhanced serum levels of sE-selectin. Furthermore SAO-shocked rats showed histological alterations in the ileum and lung. Administration of cloricromene (2 mg/kg i.v.), an inhibitor of TNF-alpha, significantly increased survival time (225 +/- 10 min), decreased serum levels of TNF-alpha and sE-selectin, reduced leukopenia and MPO activity in the ileum (0.035 +/- 0.003 U x 10(-3)/g tissue) and lung (0.3 +/- 0.005 U x 10(-3)/g tissue), improved the cardiovascular changes, and reduced the histological changes in the ileum and lung. Finally, an anti-E-selectin antibody protected rats against SAO shock. Our findings are consistent with an involvement of E-selectin, “in vivo,” in the pathogenesis of SAO shock.

Splanchnic artery occlusion (SAO) shock in the rat and tumor necrosis factor (TNF)

1990 ◽  
Vol 22 ◽  
pp. 472
Author(s):  
R. Sturniolo ◽  
F. Squadrito ◽  
D. Altavilla ◽  
A. Arena ◽  
M. Ioculano ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Artery Occlusion ◽  
Splanchnic Artery ◽  
Necrosis Factor

Platelet-activating factor, tumor necrosis factor, hypoxia and necrotizing enterocolitis

1994 ◽  
Vol 83 (s396) ◽  
pp. 11-17 ◽  
Author(s):  
W Hsueh ◽  
MS Caplan ◽  
X Sun ◽  
X Tan ◽  
W MacKendrick ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Necrotizing Enterocolitis ◽  
Tumor Necrosis ◽  
Platelet Activating Factor ◽  
Necrosis Factor
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