Nerve growth factor accelerates the early cellular events associated with wound healing

1985 ◽  
Vol 43 (2) ◽  
pp. 274-281 ◽  
Author(s):  
Michael J.P. Lawman ◽  
Michael D.P. Boyle ◽  
Adrian P. Gee ◽  
Michael Young
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Cellular Events

scholarly journals Role of Nerve Growth Factor in Cutaneous Wound Healing: Accelerating Effects in Normal and Healing-impaired Diabetic Mice

1998 ◽  
Vol 187 (3) ◽  
pp. 297-306 ◽  
Author(s):  
Hiroshi Matsuda ◽  
Hiromi Koyama ◽  
Hiroaki Sato ◽  
Junko Sawada ◽  
Atsuko Itakura ◽  
...  
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Granulation Tissue ◽  
Messenger Rna ◽  
Biological Activities ◽  
Serum Levels ◽  
Blood Stream ◽  
Diabetic Mice ◽  
Nerve Growth

Four full-thickness skin wounds made in normal mice led to the significant increase in levels of nerve growth factor (NGF) in sera and in wounded skin tissues. Since sialoadenectomy before the wounds inhibited the rise in serum levels of NGF, the NGF may be released from the salivary gland into the blood stream after the wounds. In contrast, the fact that messenger RNA and protein of NGF were detected in newly formed epithelial cells at the edge of the wound and fibroblasts consistent with the granulation tissue produced in the wound space, suggests that NGF was also produced at the wounded skin site. Topical application of NGF into the wounds accelerated the rate of wound healing in normal mice and in healing-impaired diabetic KK/Ta mice. This clinical effect of NGF was evaluated by histological examination; the increases in the degree of reepithelialization, the thickness of the granulation tissue, and the density of extracellular matrix were observed. NGF also increased the breaking strength of healing linear wounds in normal and diabetic mice. These findings suggested that NGF immediately and constitutively released in response to cutaneous injury may contribute to wound healing through broader biological activities, and NGF improved the diabetic impaired response of wound healing.

Nerve growth factor accelerates wound healing in diabetic mice

2004 ◽  
Vol 12 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Pornprom Muangman ◽  
Lara A. Muffley ◽  
Joanne P. Anthony ◽  
Michelle L. Spenny ◽  
Robert A. Underwood ◽  
...  
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Diabetic Mice ◽  
Nerve Growth

Epalrestat Improves Diabetic Wound Healing via Increased Expression of Nerve Growth Factor

2013 ◽  
Vol 121 (02) ◽  
pp. 84-89 ◽  
Author(s):  
O. Nakagaki ◽  
H. Miyoshi ◽  
T. Sawada ◽  
T. Atsumi ◽  
T. Kondo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Diabetic Wound ◽  
Nerve Growth ◽  
Diabetic Wound Healing

Nerve growth factor and corneal wound healing in dogs

2005 ◽  
Vol 80 (5) ◽  
pp. 633-642 ◽  
Author(s):  
Heung-Myong Woo ◽  
Ellison Bentley ◽  
Sean F. Campbell ◽  
Carl F. Marfurt ◽  
Christopher J. Murphy
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Corneal Wound Healing ◽  
Nerve Growth ◽  
Corneal Wound

scholarly journals The functions of nerve growth factor and nerve growth factor receptor in wound healing

2012 ◽  
Vol 16 (3+4) ◽  
pp. 51-65 ◽  
Author(s):  
Masahiko Mori ◽  
Toshiro Yamamoto ◽  
Takeshi Amemiya ◽  
Narisato Kanamura ◽  
Tetsunari Nishikawa ◽  
...  
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Nerve Growth Factor Receptor ◽  
Nerve Growth

scholarly journals The effect of the platelet derived wound healing formula and the nerve growth factor on the experimentally injured spinal cord

Spinal Cord ◽  
1996 ◽  
Vol 34 (7) ◽  
pp. 394-402 ◽  
Author(s):  
Y Hiraizumi ◽  
E Fujimaki ◽  
E E Transfeldt ◽  
N Kawahara ◽  
V D Fiegel ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Injured Spinal Cord ◽  
Nerve Growth
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