Expression of Nerve Growth Factor during Corneal Epithelial Wound Healing in Rats

2011 ◽  
Vol 52 (5) ◽  
pp. 597
Author(s):  
Hye Young Shin ◽  
Ji Wook Yang ◽  
Young Chun Lee ◽  
Su Young Kim
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Corneal Epithelial ◽  
Epithelial Wound Healing

scholarly journals Role of Nerve Growth Factor in Cutaneous Wound Healing: Accelerating Effects in Normal and Healing-impaired Diabetic Mice

1998 ◽  
Vol 187 (3) ◽  
pp. 297-306 ◽  
Author(s):  
Hiroshi Matsuda ◽  
Hiromi Koyama ◽  
Hiroaki Sato ◽  
Junko Sawada ◽  
Atsuko Itakura ◽  
...  
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Granulation Tissue ◽  
Messenger Rna ◽  
Biological Activities ◽  
Serum Levels ◽  
Blood Stream ◽  
Diabetic Mice ◽  
Nerve Growth

Four full-thickness skin wounds made in normal mice led to the significant increase in levels of nerve growth factor (NGF) in sera and in wounded skin tissues. Since sialoadenectomy before the wounds inhibited the rise in serum levels of NGF, the NGF may be released from the salivary gland into the blood stream after the wounds. In contrast, the fact that messenger RNA and protein of NGF were detected in newly formed epithelial cells at the edge of the wound and fibroblasts consistent with the granulation tissue produced in the wound space, suggests that NGF was also produced at the wounded skin site. Topical application of NGF into the wounds accelerated the rate of wound healing in normal mice and in healing-impaired diabetic KK/Ta mice. This clinical effect of NGF was evaluated by histological examination; the increases in the degree of reepithelialization, the thickness of the granulation tissue, and the density of extracellular matrix were observed. NGF also increased the breaking strength of healing linear wounds in normal and diabetic mice. These findings suggested that NGF immediately and constitutively released in response to cutaneous injury may contribute to wound healing through broader biological activities, and NGF improved the diabetic impaired response of wound healing.

Nerve growth factor accelerates the early cellular events associated with wound healing

1985 ◽  
Vol 43 (2) ◽  
pp. 274-281 ◽  
Author(s):  
Michael J.P. Lawman ◽  
Michael D.P. Boyle ◽  
Adrian P. Gee ◽  
Michael Young
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Cellular Events

scholarly journals Nerve Growth Factor Promotes Corneal Epithelial Migration by Enhancing Expression of Matrix Metalloprotease-9

2013 ◽  
Vol 54 (6) ◽  
pp. 3880 ◽  
Author(s):  
Tomas Blanco-Mezquita ◽  
Carmen Martinez-Garcia ◽  
Rui Proença ◽  
James D. Zieske ◽  
Stefano Bonini ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Matrix Metalloprotease ◽  
Nerve Growth ◽  
Corneal Epithelial ◽  
Epithelial Migration

scholarly journals Nerve growth factor and its receptor TrkA serve as potential markers for human corneal epithelial progenitor cells

2008 ◽  
Vol 86 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Hong Qi ◽  
De-Quan Li ◽  
H. David Shine ◽  
Zhuo Chen ◽  
Kyung-Chul Yoon ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Progenitor Cells ◽  
Nerve Growth ◽  
Corneal Epithelial ◽  
Epithelial Progenitor Cells

Nerve growth factor accelerates wound healing in diabetic mice

2004 ◽  
Vol 12 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Pornprom Muangman ◽  
Lara A. Muffley ◽  
Joanne P. Anthony ◽  
Michelle L. Spenny ◽  
Robert A. Underwood ◽  
...  
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Diabetic Mice ◽  
Nerve Growth

Epalrestat Improves Diabetic Wound Healing via Increased Expression of Nerve Growth Factor

2013 ◽  
Vol 121 (02) ◽  
pp. 84-89 ◽  
Author(s):  
O. Nakagaki ◽  
H. Miyoshi ◽  
T. Sawada ◽  
T. Atsumi ◽  
T. Kondo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Diabetic Wound ◽  
Nerve Growth ◽  
Diabetic Wound Healing
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