scholarly journals Role of microtubules in bile acid transport in isolated rat hepatocytes

1978 ◽  
Vol 74 (5) ◽  
pp. 1073 ◽  
Author(s):  
E.J. Olinger ◽  
E.S. Hercker ◽  
J.D. Ostrow
Keyword(s):  
Bile Acid ◽  
Rat Hepatocytes ◽  
Acid Transport ◽  
Isolated Rat Hepatocytes ◽  
Bile Acid Transport ◽  
Isolated Rat

Transport characteristics of three fluorescent conjugated bile acid analogs in isolated rat hepatocytes and couplets

Hepatology ◽  
1995 ◽  
Vol 22 (2) ◽  
pp. 637-647 ◽  
Author(s):  
Lilia M. Maglova ◽  
Angela M. Jackson ◽  
Xue-Jun Meng ◽  
Michael W. Carruth ◽  
Claudio D. Schteingart ◽  
...  
Keyword(s):  
Bile Acid ◽  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat

scholarly journals Taurolithocholate and taurolithocholate 3-sulphate exert different effects on cytosolic free Ca2+ concentration in rat hepatocytes

1994 ◽  
Vol 300 (2) ◽  
pp. 383-386 ◽  
Author(s):  
I Marrero ◽  
A Sanchez-Bueno ◽  
P H Cobbold ◽  
C J Dixon
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Rat Hepatocytes ◽  
Signalling Pathway ◽  
Common Mechanism ◽  
Isolated Rat Hepatocytes ◽  
Isolated Rat

Single rat hepatocytes show repetitive oscillations in cytosolic free Ca2+ concentration ([Ca2+]i) when stimulated by agonists acting through the phosphoinositide signalling pathway. We have studied the effect of a natural bile acid, taurolithocholate (TLC), and its sulphated form, taurolithocholate 3-sulphate (TLC-S), on [Ca2+]i in single isolated rat hepatocytes. Although these bile acids are believed to act through a common mechanism to permeabilize the intracellular Ca2+ pool, the [Ca2+]i responses induced by the two compounds were different. Whereas TLC induced a sustained elevation of [Ca2+]i, TLC-S evoked repetitive [Ca2+]i oscillations. In addition, we show that ryanodine, which blocks the Ca(2+)-induced Ca2+ release (‘CICR’) mechanism, blocked TLC-S-induced oscillations in 50% of hepatocytes, but did not affect the TLC-induced rise in [Ca2+]i.

P413 ROLE OF KINASES EGFR AND SRC IN ESTRADIOL 17β-GLUCURONIDE (E17G) INDUCED CHOLESTASIS IN ISOLATED RAT HEPATOCYTES COUPLETS (IRHC)

2014 ◽  
Vol 60 (1) ◽  
pp. S205-S206
Author(s):  
I.R. Barosso ◽  
A.E. Zucchetti ◽  
G.S. Miszczuk ◽  
M.G. Roma ◽  
F.A. Crocenzi ◽  
...  
Keyword(s):  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Estradiol 17Β ◽  
Isolated Rat
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