Endogenous nitric oxide modulates ethanol-induced gastric mucosal injury in rats

1995 ◽  
Vol 108 (1) ◽  
pp. 58-64 ◽  
Author(s):  
Eiji Masuda ◽  
Sunao Kawano ◽  
Kouichi Nagano ◽  
Shingo Tsuji ◽  
Yoshiyuki Takei ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury ◽  
Endogenous Nitric Oxide

Role of endogenous nitric oxide synthase inhibitor in gastric mucosal injury

2008 ◽  
Vol 86 (3) ◽  
pp. 97-104 ◽  
Author(s):  
Li Wang ◽  
Yuan Zhou ◽  
Jun Peng ◽  
Zhe Zhang ◽  
De-Jian Jiang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury ◽  
Epithelial Cell Line ◽  
Tnf Α ◽  
Endogenous Nitric Oxide ◽  
Injury Models ◽  
Oxide Synthase

To explore the role of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) in gastric mucosal injury, 3 models of gastric mucosal injury induced by ethanol, indomethacin, or cold stress were used in rats. The cultured human gastric mucosal epithelial cell line GES-1 infected by Helicobacter pylori (Hp) was selected to mimic human gastric mucosal injury. Gastric mucosal ulcer index (UI), levels of ADMA and NO, and activity of dimethylarginine dimethylaminohydrolase (DDAH) were determined in the mucosal injury models; in Hp-infected or ADMA-treated GES-1 cells, levels of ADMA, NO, and TNF-α and activity of DDAH were measured. The results showed that UI and levels of ADMA were markedly increased and accompanied by significantly decreased DDAH activity in the mucosal injury models. Incubation of GES-1 cells with Hp increased levels of TNF-α and ADMA and decreased activity of DDAH. Administration of ADMA also increased levels of TNF-α. The results suggest that ADMA plays an important role in facilitating gastric mucosal injury, an effect which is associated with inhibiting NO synthesis and inducing inflammatory reaction.

Effect of Nitric Oxide on Stress-Induced Gastric Mucosal Injury in the Rat

Digestion ◽  
1997 ◽  
Vol 58 (4) ◽  
pp. 311-318 ◽  
Author(s):  
Hidenori Yu ◽  
Eisuke F. Sato ◽  
Yukiko Minamiyama ◽  
Tetsuo Arakawa ◽  
Kenzo Kobayashi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury

Role of nitric oxide and histamine in the reflux-related gastric mucosal injury in the rat

1999 ◽  
Vol 48 (0) ◽  
pp. 102-103
Author(s):  
E. Masini ◽  
M. Fazi ◽  
R. Baronti ◽  
P. F. Mannaioni ◽  
P. Bechi <!-RID="h1"--> <!-ID=
Keyword(s):  
Nitric Oxide ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury
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