Role of Endothelin-converting Enzyme-1 in the Suppression of Constitutive Nitric Oxide Synthase in Rat Gastric Mucosal Injury by Indomethacin

2000 ◽  
Vol 35 (11) ◽  
pp. 1131-1136 ◽  
Author(s):  
B. L. Slomiany, A. Slomiany
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury ◽  
Converting Enzyme ◽  
Endothelin Converting Enzyme ◽  
Constitutive Nitric Oxide Synthase ◽  
Oxide Synthase

Role of endogenous nitric oxide synthase inhibitor in gastric mucosal injury

2008 ◽  
Vol 86 (3) ◽  
pp. 97-104 ◽  
Author(s):  
Li Wang ◽  
Yuan Zhou ◽  
Jun Peng ◽  
Zhe Zhang ◽  
De-Jian Jiang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury ◽  
Epithelial Cell Line ◽  
Tnf Α ◽  
Endogenous Nitric Oxide ◽  
Injury Models ◽  
Oxide Synthase

To explore the role of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) in gastric mucosal injury, 3 models of gastric mucosal injury induced by ethanol, indomethacin, or cold stress were used in rats. The cultured human gastric mucosal epithelial cell line GES-1 infected by Helicobacter pylori (Hp) was selected to mimic human gastric mucosal injury. Gastric mucosal ulcer index (UI), levels of ADMA and NO, and activity of dimethylarginine dimethylaminohydrolase (DDAH) were determined in the mucosal injury models; in Hp-infected or ADMA-treated GES-1 cells, levels of ADMA, NO, and TNF-α and activity of DDAH were measured. The results showed that UI and levels of ADMA were markedly increased and accompanied by significantly decreased DDAH activity in the mucosal injury models. Incubation of GES-1 cells with Hp increased levels of TNF-α and ADMA and decreased activity of DDAH. Administration of ADMA also increased levels of TNF-α. The results suggest that ADMA plays an important role in facilitating gastric mucosal injury, an effect which is associated with inhibiting NO synthesis and inducing inflammatory reaction.

Role of constitutive nitric oxide synthase and peroxynitrite production in a rat model of splanchnic artery occlusion shock

Life Sciences ◽  
1998 ◽  
Vol 63 (9) ◽  
pp. 789-799 ◽  
Author(s):  
Salvatore Cuzzocrea ◽  
Basilia Zingarelli ◽  
Achille P. Caputi
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Rat Model ◽  
Artery Occlusion ◽  
Splanchnic Artery ◽  
Constitutive Nitric Oxide Synthase ◽  
Oxide Synthase

A novel role of interleukin-1-converting enzyme in cytokine-mediated inducible nitric oxide synthase gene expression: Implications for neuroinflammatory diseases

2007 ◽  
Vol 34 (4) ◽  
pp. 612-620 ◽  
Author(s):  
Eric Jüttler ◽  
Eckhard Bonmann ◽  
Matthias Spranger ◽  
Victoria Kolb-Bachofen ◽  
Christoph V. Suschek
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Interleukin 1 ◽  
Converting Enzyme ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide
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