The lack of targeting selection to lysosome limits the application of graphene quantum dots (GQDs) in the diagnosis and treatment of lysosome-related disease. In this study, we developed a facile, environmentally friendly and large-scale method to prepare [Formula: see text]-aminomorpholine (Am)-modified GQDs (Am-GQDs) via a simple hydrothermal method. The physicochemical, optical, biocompatible and targeted imaging properties were evaluated systematically. The results indicated that the synthesized Am-GQDs had a uniform size distribution and the size was around 2[Formula: see text]nm. In addition, the synthesized Am-GQDs had excellent optical properties, fluorescent stability, and good biocompatibility. More importantly, they can selectively target and image lysosome in a relatively short coculture time with cells, demonstrating their application potential in the diagnosis and treatment of lysosomal-related diseases.
Synthesis large-scale high-purity InP crystal by P-injection method
