Surface antigens on cercariae, schistosomula and adult worms of Schistosoma mansoni

SUMMARYA temporal study of the effects on the tegument of Schistosoma mansoni adult worm following in vivo praziquantel and oxamniquine treatment was performed. Drug-induced damage to the tegument, exposure of surface antigens and attachment of host antibody occurred rapidly, within 1 h, following praziquantel treatment. Oxamniquine-treated worms required 4–8 days for these effects to be apparent. The 2 drugs differed in the degree and sites of damage on the worm surface. The administration of 2 different polyspecific rabbit sera with drug significantly increased the efficacy of praziquantel when administered with the drug, but not when given 6–9 days after drug treatment. In contrast, only 1 serum was synergistic with oxamniquine when administered with drug and both sera were synergistic when given 6–9 days after drug treatment. The effect of immune killing of drug-treated worms is discussed.

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Isolation and characterization of surface antigens from Schistosoma mansoni schistosomula

Molecular and Biochemical Parasitology ◽

10.1016/0166-6851(81)90053-0 ◽

1981 ◽

Vol 3 (4) ◽

pp. 215-225 ◽

Cited By ~ 60

Author(s):

Colette Dissous ◽

Claude Dissous ◽

André Capron

Keyword(s):

Schistosoma Mansoni ◽

Surface Antigens ◽

Isolation And Characterization

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Schistosoma mansoni: Antigen preparations which induce antibodies to schistosomula surface antigens

Experimental Parasitology ◽

10.1016/0014-4894(85)90034-7 ◽

1985 ◽

Vol 60 (3) ◽

pp. 294-303 ◽

Cited By ~ 5

Author(s):

F. Hackett ◽

A.J.G. Simpson ◽

M. Knight ◽

P. Ali ◽

G. Payares ◽

...

Keyword(s):

Schistosoma Mansoni ◽

Surface Antigens

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Surface antigens of and cross-protection between two geographical isolates ofSchistosoma mansoni

Parasitology ◽

10.1017/s0031182000053968 ◽

1987 ◽

Vol 94 (2) ◽

pp. 301-312 ◽

Cited By ~ 6

Author(s):

F. Hackett ◽

A. J. G. Simpson ◽

P. Omer-Ali ◽

S. R. Smithers

Keyword(s):

Puerto Rico ◽

Schistosoma Mansoni ◽

Puerto Rican ◽

Surface Antigens ◽

Immune Mouse ◽

Human Patient ◽

Major Surface ◽

Egyptian Isolate ◽

Additional Antigen

SUMMARYTwo isolates ofSchistosoma mansonifrom Puerto Rico and Egypt were examined to determine if there were differences in surface antigens of the schistosomulum and to assess the ability of the two isolates to induce protection against one anotherin vivo. Immune mouse and human patient antisera recognized the same antigens on the schistosomulum surface of both isolates. However, mice immunized with schistosomula-released products from the Egyptian isolate recognized an additional antigen ofMr13K on the Egyptian schistosomulum surface which was not present in the Puerto Rican isolate. In quantitative radioimmunoassay, sera from mice vaccinated with irradiated Egyptian cercariae bound more strongly to Egyptian schistosomula than to Puerto Rican parasites. Both isolates cross-protected against each other, but mice were less immune to challenge with Egyptian cercariae after being immunized with Puerto Rican irradiated cercariae. There was no difference in immunity to challenge when Egyptian irradiated cercariae were used to immunize. Although this evidence suggested some heterogeneity within the Egyptian isolate, cloned cercariae of the Egyptian isolate did not vary in their ability to cross-protect against each other. Furthermore, antisera from mice immunized with clones of Egyptian cercariae recognized the same schistosomulum surface antigens. The results reported here indicate that although there were small differences between the two isolates the major surface antigens are conserved.

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