Traditional bearings with one degree of freedom (1-DOF) translation are due to sliding between rigid bodies; however, the wear, backlash, and low precision are existing defects. For high-precision mechanism to overcome these limitations, a flexible bearing with 1-DOF translation in this paper is designed alternatively by the use of the concept of compliant mechanism because its motion replies on elastic elements. Besides, the fatigue strength, fracture, and crack are frequently appeared as mechanical failures due to high stress at the fixed end of flexible hinges. To reduce mechanical failures, experiments are conducted by an L27orthogonal array of the Taguchi multiple quality method to optimize design parameters, including an applied force and the length, width, thickness, and filleted radius of flexible hinges considering the stress concentration. The results demonstrate that the resulting stress of the new design flexible bearing is almost 99.7% smaller than that of the original design.