Mobile phase selection for high-performance liquid chromatographic analysis of novel zinc(II) carboxylates with N-donor ligands

1994 ◽  
Vol 660 (1-2) ◽  
pp. 67-73 ◽  
Author(s):  
A. Oriňák ◽  
K. Gyoryová ◽  
E. Matisová ◽  
L. Šlesárová ◽  
J. Skoršepa ◽  
...  
Keyword(s):  
Chromatographic Analysis ◽  
Mobile Phase ◽  
High Performance ◽  
High Performance Liquid Chromatographic ◽  
Donor Ligands ◽  
Phase Selection ◽  
Liquid Chromatographic Analysis ◽  
Selection For ◽  
Liquid Chromatographic

Liquid chromatographic analysis of disopyramide and its mono-N-dealkylated metabolite.

1979 ◽  
Vol 25 (3) ◽  
pp. 405-408 ◽  
Author(s):  
J J Lima
Keyword(s):  
Chromatographic Analysis ◽  
Mobile Phase ◽  
High Performance ◽  
Antiarrhythmic Drugs ◽  
Internal Standard ◽  
High Performance Liquid Chromatographic ◽  
Coefficients Of Variation ◽  
Liquid Chromatographic Analysis ◽  
Liquid Chromatographic ◽  
Lower Limits

Abstract We describe a rapid, sensitive, and specific "high performance" liquid chromatographic analysis for disopyramide and its mono-N-dealkylated metabolite in serum, urine, and saliva. We used a mu-Bondapak CN column and an acetate buffer mobile phase containing methanol. Retention times for the two compounds and the internal standard, p-chlorodisopyramide, were 3.4, 4.1, and 6.3 min, respectively. The lower limits of sensitivity for drug and metabolite were 50 and 80 micrograms/L, respectively, with maximum coefficients of variation of 4.6 and 12%, respectively. Currently used antiarrhythmic drugs did not interfere with the analysis of disopyramide, and the pharmacokinetics of the drug, obtained from studies of one subject, agree well with reported values.

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