A simple screening assay for substance affecting lymphocyte reactivity

1976 ◽  
Vol 12 (1-2) ◽  
pp. 141-147 ◽  
Author(s):  
John L. Pauly
Keyword(s):  
Screening Assay ◽  
Simple Screening ◽  
Lymphocyte Reactivity

A simple screening assay for receptor switching of avian influenza viruses

2008 ◽  
Vol 42 (2) ◽  
pp. 186-189 ◽  
Author(s):  
Ornpreya Suptawiwat ◽  
Alita Kongchanagul ◽  
Wisoot Chan-It ◽  
Arunee Thitithanyanont ◽  
Witawat Wiriyarat ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Influenza Viruses ◽  
Avian Influenza Viruses ◽  
Screening Assay ◽  
Simple Screening

scholarly journals HDAC inhibitor Givinostat targets DNA-binding of human CGGBP1

2020 ◽  
Author(s):  
Manthan Patel ◽  
Divyesh Patel ◽  
Subhamoy Datta ◽  
Umashankar Singh
Keyword(s):  
Dna Binding ◽  
Protein Interactions ◽  
Histone Deacetylases ◽  
Antineoplastic Agent ◽  
Dna Binding Protein ◽  
Dna Interaction ◽  
Cancer Cell Proliferation ◽  
Screening Assay ◽  
Chemical Inhibitors ◽  
Simple Screening

ABSTRACTThe antineoplastic agent Givinostat inhibits histone deacetylases. We present here our finding that the DNA-binding of human CGGBP1 is also inhibited by Givinostat. CGGBP1, a DNA-binding protein, is required for cancer cell proliferation. In our quest to exploit the potential anti-proliferative effects of CGGBP1 inhibition, we have developed a simple screening assay to identify chemical inhibitors of DNA-protein interactions. We have applied this screen for human CGGBP1 on a library of 1685 compounds and found that Givinostat is a direct inhibitor of CGGBP1-DNA interaction. The mechanism of action of Givinostat should thus extend beyond HDACs to include the inhibition of the myriad functions of CGGBP1 that depend on its binding to the DNA.

scholarly journals HDAC inhibitor Givinostat targets DNA-binding of human CGGBP1

2020 ◽  
Author(s):  
Manthan Patel ◽  
Divyesh Patel ◽  
Subhamoy Datta ◽  
Umashankar Singh
Keyword(s):  
Dna Binding ◽  
Protein Interactions ◽  
Histone Deacetylases ◽  
Antineoplastic Agent ◽  
Dna Binding Protein ◽  
Dna Interaction ◽  
Cancer Cell Proliferation ◽  
Screening Assay ◽  
Chemical Inhibitors ◽  
Simple Screening

Abstract The antineoplastic agent Givinostat inhibits histone deacetylases. We present here our finding that the DNA-binding of human CGGBP1 is also inhibited by Givinostat. CGGBP1, a DNA-binding protein, is required for cancer cell proliferation. In our quest to exploit the potential anti-proliferative effects of CGGBP1 inhibition, we have developed a simple screening assay to identify chemical inhibitors of DNA-protein interactions. We have applied this screen for human CGGBP1 on a library of 1685 compounds and found that Givinostat is a direct inhibitor of CGGBP1-DNA interaction. The mechanism of action of Givinostat should thus extend beyond HDACs to include the inhibition of the myriad functions of CGGBP1 that depend on its binding to the DNA.

A Simple Screening Assay for Certain Fibrinolysis Parameters (FIPA)

2000 ◽  
Vol 97 (4) ◽  
pp. 231-237 ◽  
Author(s):  
Thomas W Stief ◽  
Frauke Hinz ◽  
Jürgen Kurz ◽  
Manfred O Doss ◽  
Volker Kretschmer
Keyword(s):  
Screening Assay ◽  
Simple Screening

scholarly journals A simple screening assay for the most common JK*0 alleles revealed compound heterozygosity in Jk(a-b-) probands from Guam

2020 ◽  
Vol 25 (4) ◽  
pp. 165-169
Author(s):  
Elisabet Sjöberg Wester ◽  
Julia Gustafsson ◽  
Beverly Snell ◽  
Peggy Spruell ◽  
Åsa Hellberg ◽  
...  
Keyword(s):  
Compound Heterozygosity ◽  
Screening Assay ◽  
Simple Screening

scholarly journals HDAC inhibitor Givinostat targets DNA-binding of human CGGBP1

2020 ◽  
Author(s):  
Manthan Patel ◽  
Divyesh Patel ◽  
Subhamoy Datta ◽  
Umashankar Singh
Keyword(s):  
Dna Binding ◽  
Protein Interactions ◽  
Histone Deacetylases ◽  
Antineoplastic Agent ◽  
Dna Binding Protein ◽  
Dna Interaction ◽  
Cancer Cell Proliferation ◽  
Screening Assay ◽  
Chemical Inhibitors ◽  
Simple Screening

Abstract The antineoplastic agent Givinostat inhibits histone deacetylases. We present here our finding that the DNA-binding of human CGGBP1 is also inhibited by Givinostat. CGGBP1, a DNA-binding protein, is required for cancer cell proliferation. In our quest to exploit the potential anti-proliferative effects of CGGBP1 inhibition, we have developed a simple screening assay to identify chemical inhibitors of DNA-protein interactions. We have applied this screen for human CGGBP1 on a library of 1685 compounds and found that Givinostat is a direct inhibitor of CGGBP1-DNA interaction. The mechanism of action of Givinostat should thus extend beyond HDACs to include the inhibition of the myriad functions of CGGBP1 that depend on its binding to the DNA.

A Simple Screening Assay for Cholinesterase Activity and Inhibition Based on Optical Oxygen Detection

2010 ◽  
Vol 43 (10-11) ◽  
pp. 1746-1755 ◽  
Author(s):  
Alice Zitova ◽  
Fiach C. O'Mahony ◽  
Ilya N. Kurochkin ◽  
Dmitri B. Papkovsky
Keyword(s):  
Cholinesterase Activity ◽  
Screening Assay ◽  
Oxygen Detection ◽  
Simple Screening

The PACT—A simple screening assay for assessing the functionality of the protein C anticoagulant pathway

1995 ◽  
Vol 79 (2) ◽  
pp. 217-222 ◽  
Author(s):  
Michael Kraus ◽  
Michael Noah ◽  
Karl Fickenscher
Keyword(s):  
Protein C ◽  
Screening Assay ◽  
Simple Screening
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