Treatment of human muscle creatine kinase with glutaraldehyde preferentially increases the immunogenicity of the native conformation and permits production of high-affinity monoclonal antibodies which recognize two distinct surface epitopes

1989 ◽  
Vol 125 (1-2) ◽  
pp. 251-259 ◽  
Author(s):  
Nguyen thi Man ◽  
Alison J. Cartwright ◽  
Karen M. Andrews ◽  
Glenn E. Morris
Keyword(s):  
Creatine Kinase ◽  
Monoclonal Antibodies ◽  
Human Muscle ◽  
Native Conformation ◽  
Muscle Creatine Kinase ◽  
High Affinity ◽  
Muscle Creatine

Mutagenesis of Two Acidic Active Site Residues in Human Muscle Creatine Kinase:  Implications for the Catalytic Mechanism†

Biochemistry ◽  
2001 ◽  
Vol 40 (10) ◽  
pp. 3056-3061 ◽  
Author(s):  
John S. Cantwell ◽  
Walter R. Novak ◽  
Pan-Fen Wang ◽  
Michael J. McLeish ◽  
George L. Kenyon ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Active Site ◽  
Catalytic Mechanism ◽  
Human Muscle ◽  
Active Site Residues ◽  
Muscle Creatine Kinase ◽  
Muscle Creatine

Isoleucine 69 and Valine 325 Form a Specificity Pocket in Human Muscle Creatine Kinase†

Biochemistry ◽  
2004 ◽  
Vol 43 (43) ◽  
pp. 13766-13774 ◽  
Author(s):  
Walter R. P. Novak ◽  
Pan-Fen Wang ◽  
Michael J. McLeish ◽  
George L. Kenyon ◽  
Patricia C. Babbitt
Keyword(s):  
Creatine Kinase ◽  
Human Muscle ◽  
Muscle Creatine Kinase ◽  
Muscle Creatine
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