Stability constant studies on some new thioether carboxylic acid chelating agents II: Derivatives of β-mercaptopropionic acid

1975 ◽  
Vol 37 (11) ◽  
pp. 2403-2407 ◽  
Author(s):  
Thomas H. Pratt ◽  
Mark M. Jones
Keyword(s):  
Carboxylic Acid ◽  
Stability Constant ◽  
Chelating Agents ◽  
Mercaptopropionic Acid ◽  
Derivatives Of

Stability constant studies on some new thioether carboxylic acid chelating agents

1975 ◽  
Vol 37 (3) ◽  
pp. 761-765 ◽  
Author(s):  
Mark M. Jones ◽  
Alton J. Banks ◽  
C. Hendricks Brown
Keyword(s):  
Carboxylic Acid ◽  
Stability Constant ◽  
Chelating Agents

scholarly journals Novel Derivatives of 4-Methyl-1,2,3-Thiadiazole-5-Carboxylic Acid Hydrazide: Synthesis, Lipophilicity, and In Vitro Antimicrobial Activity Screening

2021 ◽  
Vol 11 (3) ◽  
pp. 1180
Author(s):  
Kinga Paruch ◽  
Łukasz Popiołek ◽  
Anna Biernasiuk ◽  
Anna Berecka-Rycerz ◽  
Anna Malm ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Carboxylic Acid ◽  
Bacterial Infections ◽  
Acid Hydrazide ◽  
Antimicrobial Effect ◽  
In Vitro Antimicrobial Activity ◽  
Research Goal ◽  
New Compounds ◽  
Derivatives Of

Bacterial infections, especially those caused by strains resistant to commonly used antibiotics and chemotherapeutics, are still a current threat to public health. Therefore, the search for new molecules with potential antimicrobial activity is an important research goal. In this article, we present the synthesis and evaluation of the in vitro antimicrobial activity of a series of 15 new derivatives of 4-methyl-1,2,3-thiadiazole-5-carboxylic acid. The potential antimicrobial effect of the new compounds was observed mainly against Gram-positive bacteria. Compound 15, with the 5-nitro-2-furoyl moiety, showed the highest bioactivity: minimum inhibitory concentration (MIC) = 1.95–15.62 µg/mL and minimum bactericidal concentration (MBC)/MIC = 1–4 µg/mL.

Some Basic Derivatives of 3-Methylflavone-8-carboxylic Acid

1960 ◽  
Vol 2 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Paolo Da Re ◽  
Lucia Verlicchi ◽  
Ivo Setnikar
Keyword(s):  
Carboxylic Acid ◽  
Derivatives Of

scholarly journals Hyperbranched Molecular Structures with Potential Antiviral Activity: Derivatives of 5,6-Dihydroxyindole-2-Carboxylic Acid

Molecules ◽  
2006 ◽  
Vol 11 (12) ◽  
pp. 968-977 ◽  
Author(s):  
Mario Sechi ◽  
Fabio Casu ◽  
Ilaria Campesi ◽  
Stefano Fiori ◽  
Alberto Mariani
Keyword(s):  
Carboxylic Acid ◽  
Antiviral Activity ◽  
Molecular Structures ◽  
Derivatives Of

Heterocycles from 2-Aminopyridine and Derivatives of 3-Methylbenzofuran-2-carboxylic Acid

Heterocycles ◽  
1997 ◽  
Vol 45 (4) ◽  
pp. 787 ◽  
Author(s):  
Yvette A. Jackson ◽  
Mark F. Williams
Keyword(s):  
Carboxylic Acid ◽  
Derivatives Of

Aminoalkyl derivatives of 2,4′-bithiazole-4-carboxylic acid, the intercalating part of bleomycin

1984 ◽  
Vol 21 (3) ◽  
pp. 681-683 ◽  
Author(s):  
Raymond Houssin ◽  
Jean-Luc Bernier ◽  
Jean-Pierre Hénichart
Keyword(s):  
Carboxylic Acid ◽  
Derivatives Of

Carboxylic acid and phosphate ester derivatives of fluconazole: synthesis and antifungal activities

2004 ◽  
Vol 12 (23) ◽  
pp. 6255-6269 ◽  
Author(s):  
Nguyen-Hai Nam ◽  
Soroush Sardari ◽  
Meredith Selecky ◽  
Keykavous Parang
Keyword(s):  
Carboxylic Acid ◽  
Phosphate Ester ◽  
Antifungal Activities ◽  
Derivatives Of

scholarly journals 5-ACETYL-8-HYDROXYQUINOLINE AND 5-FORMYL-8- HYDROXYQUINOLINE: CHELATING AGENTS FOR COMPLEXOMETRIC TITRATIONS

2019 ◽  
Vol 16 (31) ◽  
pp. 765-777
Author(s):  
Roberto FERNANDEZ-MAESTRE ◽  
Alonso J MARRUGO-GONZÁLEZ
Keyword(s):  
Environmental Remediation ◽  
Chelating Agents ◽  
Organic Ligand ◽  
Formation Constants ◽  
Oxidation Reduction ◽  
Inductive Effects ◽  
Technological Developments ◽  
Metal Organic ◽  
Large Formation ◽  
Derivatives Of

Metal–organic ligand complexes are essential to many technological developments from protein supramolecular assemblies to solvent extraction, complexometric titrations, and environmental remediation. We studied the chelating and acid-base properties in ethanol of two derivatives of 8-hydroxyquinoline (Q), 5-acetyl-8-hydroxyquinoline (A) and 5-formyl-8-hydroxyquinoline (F), of which applications as chelators are unknown. The ligands acidity followed the order F (pKa1 2.9; pKa2 9.5)> A (pKa1 4.8; pKa2 9.6)> Q (pKa1 5.3; pKa2 10.0) due to inductive effects of electronegative groups, formyl in F and acetyl in A. The higher acidity of F with respect to A was due to the higher electronegativity of the formyl group in F. This acidity order was reflected in larger formation constants of F-metal complexes with pKf values of 32 (Fe3+), 27.1 (Cu2+), 26.2 (Cu2+), and 24.9 (Pb2+), than with A, with pKf values of 31, 22.5, 21.4 and 21.2 with these metals, or the pKf values in the literature for Q. In summary, A and F resulted excellent chelators for metals in complexometric titrations with large formation constants; these large formation constants recommend the application of these compounds in masking, preconcentration, and titration of metals by complexation and oxidation-reduction reactions.

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