Temperature dependence of the calcium paradox in the isolated working rat heart: Discrepancy between functional recovery and enzyme release,

1980 ◽  
Vol 12 (5) ◽  
pp. 511-517 ◽  
Author(s):  
S Digerness
Keyword(s):  
Temperature Dependence ◽  
Functional Recovery ◽  
Rat Heart ◽  
Calcium Paradox ◽  
Enzyme Release ◽  
Working Rat Heart

scholarly journals Functional recovery after dantrolene-supplementation of cold stored hearts using an ex vivo isolated working rat heart model

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0205850 ◽  
Author(s):  
Jeanette E. Villanueva ◽  
Ling Gao ◽  
Hong C. Chew ◽  
Mark Hicks ◽  
Aoife Doyle ◽  
...  
Keyword(s):  
Functional Recovery ◽  
Rat Heart ◽  
Ex Vivo ◽  
Heart Model ◽  
Working Rat Heart

Metabolic recovery of isolated working rat heart after brief global ischemia

1994 ◽  
Vol 267 (2) ◽  
pp. H462-H470 ◽  
Author(s):  
G. W. Goodwin ◽  
H. Taegtmeyer
Keyword(s):  
Functional Recovery ◽  
Rat Heart ◽  
Recovery Of Function ◽  
Glycogen Depletion ◽  
Beta Hydroxybutyrate ◽  
Postischemic Recovery ◽  
Working Rat Heart ◽  
Pyruvate Ratio

Functional recovery following ischemia and reperfusion in the isolated working rat heart perfused with glucose (11 mM) was examined in relation to pre- and postischemic levels of ATP, glycogen, glucose 6-phosphate, and the lactate-to-pyruvate ratio. The following variables were studied: feeding and fasting in vivo, addition of L-lactate (10 mM), dl-beta-hydroxybutyrate (10 mM), glucagon (0.01 and 1 micrograms/ml), and a 15-min anoxic perfusion before ischemia in vitro. Recovery was assessed as the percentage of preischemic power. Good correlation was found between functional recovery and the postischemic content of glycogen. Glycogen depletion by anoxia or glucagon before ischemia impaired recovery. There was no relationship among lactate produced, or the lactate-to-pyruvate ratio, and recovery. The addition of lactate or beta-hydroxybutyrate to hearts from fed rats increased the content of glycogen and glucose 6-phosphate, whereas addition of lactate, but not beta-hydroxybutyrate, improved recovery. There was a linear relationship between glycogen content and glucose 6-phosphate levels. In conclusion, the degree of return of oxidative metabolism and of net glycogen resynthesis reflects postischemic recovery of function. The results also suggest a role for anaplerosis of the citric acid cycle as an additional determinant of postischemic recovery.

scholarly journals Transient reperfusion with acidic solution affects postischemic functional recovery: Studies in the isolated working rat heart

1996 ◽  
Vol 111 (3) ◽  
pp. 613-620 ◽  
Author(s):  
Takeki Ohashi ◽  
Fumio Yamamoto ◽  
Hiroshi Yamamoto ◽  
Hajime Ichikawa ◽  
Toshihiko Shibata ◽  
...  
Keyword(s):  
Functional Recovery ◽  
Rat Heart ◽  
Acidic Solution ◽  
Working Rat Heart
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