Synergistic effects of hemodynamic stabilization and beta-blockade on arrhythmias in a pig-model of acute myocardial ischemia. (AMI)

1992 ◽  
Vol 24 ◽  
pp. 262
Author(s):  
Cecilia A Muller ◽  
Alexandros C Kralios ◽  
Lionel H Opie
Keyword(s):  
Myocardial Ischemia ◽  
Synergistic Effects ◽  
Acute Myocardial Ischemia ◽  
Pig Model ◽  
Beta Blockade

A555 HIGH DOSE beta-BLOCKADE AS AN ALTERNATIVE FOR MYOCARDIAL PROTECTION IN ACUTE MYOCARDIAL ISCHEMIA

1997 ◽  
Vol 87 (Supplement) ◽  
pp. 555A
Author(s):  
H.J. Geissler ◽  
&NA; Allen ◽  
K.L. Davis ◽  
&NA; Warters ◽  
E.R. deVivie ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Myocardial Protection ◽  
Acute Myocardial Ischemia ◽  
Beta Blockade ◽  
High Dose

Critical Role of Dose in Protection by Propranolol Against Ventricular Fibrillation in a Pig Model of Acute Myocardial Ischemia

1989 ◽  
Vol 13 (2) ◽  
pp. 192-197 ◽  
Author(s):  
Cecilia A. Muller ◽  
Lionel H. Opie ◽  
Max Peisach ◽  
Carlos A. Pineda ◽  
Christian W. Hamm ◽  
...  
Keyword(s):  
Ventricular Fibrillation ◽  
Myocardial Ischemia ◽  
Critical Role ◽  
Acute Myocardial Ischemia ◽  
Pig Model

Heparin from Intestine and Lung Source Administered in Large Dose to Dogs with Acute Myocardial Ischemia

1978 ◽  
Vol 40 (02) ◽  
pp. 407-417
Author(s):  
Michael J Saliba ◽  
Richard J Pavalec
Keyword(s):  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Adenosine Triphosphate ◽  
Intestinal Mucosa ◽  
Large Dose ◽  
Acute Myocardial Ischemia ◽  
Ischemic Myocardium ◽  
Atp Levels ◽  
Initial Control ◽  
The Difference

SummaryIntestinal mucosa heparin (IMH) and beef lung heparin (BLH) were infused into dogs subjected to myocardial ischemia by intermittent coronary artery occlusions. The IMH was from a mixture of beef, sheep, and pig intestinal mucosa. Initial control occlusion and recovery was followed by a second occlusion with 60,000 units of IMH or BLH added. Electrocardiographic S-T segment elevations (ST) were measured acutely. There were no significant differences in ST in non-ischemic myocardium before occlusions or with occlusions. In ischemic myocardium, IMH significantly lowered control ST 84% in amount (t = 6.1 p <0.00005), and 76% in number (t = 11.6 p <0.00001). BLH lowered control ST a significant, lesser, 36% in amount (t = 3.6 p <0.008), and 35% in number (t = 3.2 p <0.01). The difference between IMH and BLH in ischemic myocardium was a significant 48% in amount (t = 4.0 p <0.0007), and 41% in number (t = 2.0 p <0.06). Myocardial adenosine triphosphate (ATP) levels were assayed after 90 min. ATP levels were 31% higher in both ischemic and non-ischemic myocardium in IMH-treated dogs than in BLH- treated. It was concluded that IMH and BLH are functionally different, and IMH was significantly more effective.

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