Delayed surgery for congenital diaphragmatic hernia: Neurodevelopmental outcome in later childhood

1994 ◽  
Vol 29 (5) ◽  
pp. 707
Author(s):  
David M. Burge
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Neurodevelopmental Outcome ◽  
Delayed Surgery

CONGENITAL DIAPHRAGMATIC HERNIA: SURVIVAL TREATED WITH VERY DELAYED SURGERY, SPONTANEOUS RESPIRATION, AND NO CHEST TUBE

PEDIATRICS ◽  
1996 ◽  
Vol 97 (6) ◽  
pp. 810-810
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Retrospective Review ◽  
Chest Tube ◽  
Surgical Repair ◽  
Spontaneous Respiration ◽  
Respiratory Care ◽  
Delayed Surgery ◽  
Membrane Oxygenation

This report suggests that stabilization of the intrauterine to extrauterine transitional circulation, combined with a respiratory care strategy that avoids pulmonary overdistension, takes advantage of inherent biological cardiorespiratory mechanics, and very delayed surgery for congenital diaphragmatic hernia results in improved survival and decreases the need for extracorporeal membrane oxygenation (ECMO). This retrospective review of a 10-year experience in which the respiratory care strategy, ECMO availability, and technique of surgical repair remained essentially contant describes the evolution of this method of management of congenital diaphragmatic hernia.

Congenital Diaphragmatic Hernia: Experience with Preoperative Stabilization and Delayed Surgery without ECMO and Inhaled Nitric Oxide

1998 ◽  
Vol 15 (08) ◽  
pp. 487-490 ◽  
Author(s):  
Muneef Al-Hathal ◽  
Stanley Crankson ◽  
Fahad Al-Harbi ◽  
Gasudraz Ahmed ◽  
Khalil Tawil
Keyword(s):  
Nitric Oxide ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Inhaled Nitric Oxide ◽  
Delayed Surgery

Delayed surgery for congenital diaphragmatic hernia

1992 ◽  
Vol 79 (7) ◽  
pp. 644-646 ◽  
Author(s):  
D. W. Goh ◽  
D. P. Drake ◽  
R. J. Brereton ◽  
E. M. Kiely ◽  
L. Spitz
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Delayed Surgery

scholarly journals Neonatal neuroimaging after repair of congenital diaphragmatic hernia and long-term neurodevelopmental outcome

2019 ◽  
Vol 2 (3) ◽  
pp. e000037
Author(s):  
Julia Kate Gunn-Charlton ◽  
Alice C Burnett ◽  
Stephanie Malarbi ◽  
Margaret M Moran ◽  
Esther A Hutchinson ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Language Impairment ◽  
Neurodevelopmental Outcome ◽  
White Matter Injury ◽  
Scan Time ◽  
Mri Scans ◽  
Cerebral Ultrasound ◽  
Neurodevelopmental Impairment ◽  
Clinically Significant

ObjectivePrevious outcome reports of congenital diaphragmatic hernia (CDH) have described neuroimaging anomalies and neurodevelopmental impairment. However, the link between imaging and outcome has not been described. We aimed to determine whether routine postoperative neonatal neuroimaging in infants with CDH detects later neurodevelopmental impairment.MethodsIn a prospective cohort study within a clinical service in The Royal Children’s Hospital Newborn Intensive Care. Cerebral ultrasound was performed in 81 children and MRI in 57 children who subsequently underwent neurodevelopmental follow-up after surgery for CDH. MRI scans were analyzed using a scoring system designed to identify injury, maturation and volume loss. Neurodevelopmental assessment occurred at 2 years (48) and neurocognitive assessment at 5 years (26) and/or 8 years (27). Brain imaging scores corrected for gestational age at scan time were correlated with outcome measures, adjusting for known clinical confounders.ResultsClinically significant findings were identified on MRI of 16 (28%) infants. Mean scores were in the normal range for all domains assessed at each age. Language impairment was seen in 23% at 2 years and verbal intellectual impairment in 25% at 8 years. Mean cognitive scores were lower in 2-year-old children with white matter injury on MRI (p=0.03). Mean motor scores were lower in 2-year-old children with brain immaturity (p=0.01). Associations between MRI and 5-year and 8-year assessments were no longer significant when adjusting for known clinical confounders.ConclusionsNeuroimaging abnormalities were associated with worse neurodevelopment at 2 years, but not with later neurocognitive outcomes, after accounting for clinical risk factors.

Neurodevelopmental outcome of infants with congenital diaphragmatic hernia prospectively enrolled in an interdisciplinary follow-up program

2010 ◽  
Vol 45 (9) ◽  
pp. 1759-1766 ◽  
Author(s):  
Enrico Danzer ◽  
Marsha Gerdes ◽  
Judy Bernbaum ◽  
Joann D’Agostino ◽  
Michael W. Bebbington ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Neurodevelopmental Outcome
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