Three case reports of fetal growth retardation in the second trimester

Aim. To assess the short-term and long-term variability of blood pressure in women, starting from early pregnancy, to predict the development of complications of gestation, including preeclempsia. Methods. In 131 pregnant women, systolic blood pressure, diastolic blood pressure, as well as short-term (intra-visit) and long-term (inter-visit) blood pressure variability were assessed during the gestation period and 6 weeks after delivery. At the end of gestation period, depending on the identified complications, all study participants were divided into four groups: group 1 - control (healthy); group 2 - pregnant with preeclempsia; group 3 - with placental insufficiency; group 4 - with chronic arterial hypertension. In patients with placental insufficiency the indices of fetal growth retardation were also analyzed. Results. In group 4, starting from the second trimester, higher values of short-term blood pressure variability were demonstrated, which increased as pregnancy progressed. Long-term blood pressure variability increased in groups 2 and 4, starting from the second trimester. In pregnant women with fetal growth retardation in the first trimester, blood pressure variability was higher than in pregnant controls and in the second trimester it was higher than in the group with the subsequent development of preeclempsia. Thus, during pregnancy complicated by preeclempsia or placental insufficiency with fetal growth retardation, high long-term blood pressure variability was observed. At the same time, the highest values were observed in the third trimester. Conclusion. The assessment of long-term blood pressure variability from the early gestation seems to be an effective tool for detecting preclinical changes in the body of a pregnant woman, preceding the development of preeclempsia and fetal growth retardation, and in the presence of risk factors of preeclampsia allows narrowing the group of patients for target follow-up and prevention.

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FEATURES OF THE CLINICAL COURSE OF PREGNANCY, CHILDBIRTH IN WOMEN WITH COVID-19 AT DIFFERENT PERIODS OF GESTATION

Scientific digest of association of obstetricians and gynecologists of Ukraine ◽

10.35278/2664-0767.1(47).2021.242679 ◽

2021 ◽

pp. 39-47

Author(s):

V. P. MISHCHENKO ◽

I. L. GOLOVATYUK-YUZEFPOLSKAYA ◽

I. RUDENKO ◽

M. A. KARLYUGA ◽

A. D. DIZIK ◽

...

Keyword(s):

Amniotic Fluid ◽

Fetal Growth ◽

Growth Retardation ◽

Premature Birth ◽

Clinical Course ◽

Fetal Distress ◽

Fetal Growth Retardation ◽

Second Trimester ◽

Placental Dysfunction ◽

Threatened Abortion

The study of the features of the clinical course of pregnancy, childbirth in women who have had COVID-19 at different periods of gestation is relevant, especially in the context of a modern pandemic. Purpose of work. To determine the features of the clinical course of pregnancy, childbirth in women with COVID-19 at different periods of gestation. Materials and methods. 57 women who were ill with Covid-19 at different stages of pregnancy were examined. Results and discussion. The peculiarities of the clinical course of pregnancy, childbirth in women who have undergone Covid-19 diseases in the 1st trimesterinclude the syndrome of threatened abortion (73.6 %), placental dysfunction (100%), fetal growth retardation syndrome (42.9 %); in the second trimester - syndrome of threatened premature birth (55.6 %), placental dysfunction (100 %), amniotic fluid pathology (63.2 %); in the third trimester - anemia - in 100 %, antenatal fetal distress - in 42.1 %, pareclampsia - in 47.4 %, pathological blood loss - in 26.3 %. Conclusions. The course of pregnancy and childbirth in women who have undergone COVID-19 diseases in different trimesters of gestation have certain clinical features. Gestational complications in women who were ill in the early stages of the first trimester include the syndrome of threatened abortion, spontaneous abortion, missed abortion, premature birth in the second trimester, fetal growth retardation syndrome in the second and third trimesters. The gestational complications in women who were ill in the second trimester include the syndrome of threatened abortion, premature birth, pathology of amniotic fluid (amniotic fluid of «black» color), the phenomenon of angiitis in the abdominal cavity, placental dysfunction, fetal growth retardation syndrome, distress fetus, antenatal fetal death. The gestational complications in women who were ill in the third trimester include the syndrome of threatened premature birth, placental dysfunction, and fetal distress.

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Fetal growth retardation and second trimester maternal serum human chorionic gonadotrophin levels

Placenta ◽

10.1016/s0143-4004(98)90002-9 ◽

1998 ◽

Vol 19 (2-3) ◽

pp. 143-147 ◽

Cited By ~ 18

Author(s):

M.J.M. Luckas ◽

R. Sandland ◽

J. Hawe ◽

J.P. Neilson ◽

I.R. McFadyen ◽

...

Keyword(s):

Fetal Growth ◽

Growth Retardation ◽

Maternal Serum ◽

Chorionic Gonadotrophin ◽

Human Chorionic Gonadotrophin ◽

Fetal Growth Retardation ◽

Second Trimester

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Potent Topical Steroids Doubled Risk of Fetal Growth Retardation

Skin & Allergy News ◽

10.1016/s0037-6337(11)70259-5 ◽

2011 ◽

Vol 42 (5) ◽

pp. 12

Author(s):

BRUCE JANCIN

Keyword(s):

Fetal Growth ◽

Growth Retardation ◽

Topical Steroids ◽

Fetal Growth Retardation

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Betamethasone in the last week of pregnancy causes fetal growth retardation but not adult hypertension in rats

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(03)00151-5 ◽

2003 ◽

Vol 10 (8) ◽

pp. 469-473 ◽

Cited By ~ 16

Author(s):

T McDonald

Keyword(s):

Fetal Growth ◽

Growth Retardation ◽

Fetal Growth Retardation

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A Prospective Study of Haemostatic Tests at 28 Weeks Gestation as Predictors of Pre-Eclampsia and Growth Retardation

Thrombosis and Haemostasis ◽

10.1055/s-0038-1646567 ◽

1989 ◽

Vol 61 (02) ◽

pp. 243-245 ◽

Cited By ~ 4

Author(s):

J G Thornton ◽

B J Molloy ◽

P S Vinall ◽

P R Philips ◽

R Hughes ◽

...

Keyword(s):

Discriminant Analysis ◽

Prospective Study ◽

Fetal Growth ◽

Growth Retardation ◽

Degradation Products ◽

Fetal Growth Retardation ◽

Fibrin Degradation Products ◽

A Prospective Study ◽

Primiparous Women ◽

Significant Model

SummaryA panel of haemostatic tests was perfomed on 400 primiparous women at 28 weeks to test whether one or more could predict the development of pregnancy complications. Fifteen women subsequently developed pre-eclampsia with significant proteinuria and 13 delivered growth retarded infants. There were no significant differences between mothers in the pre-eclampsia group and 22 randomly selected controls. A stepwise logistic discriminant analysis of the data did not produce a significant model. In the growth retarded group only beta thromboglobulin levels were significantly lower than in the controls (p <0.05), although in the logistic discriminant analysis the inclusion of both beta thromboglobulin and fibrin degradation products led to a borderline significant improvement in fit of the model. We conclude that the haemostatic variables studied are not significantly changed at 28 weeks nor clinically useful predictors of either pre-eclampsia or fetal growth retardation.

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