Determination of phenothiazines by charge-transfer complex formation with chloranilic acid

Talanta ◽  
1986 ◽  
Vol 33 (2) ◽  
pp. 111-114 ◽  
Author(s):  
N.A. Zakhari ◽  
M. Rizk ◽  
F. Ibrahim ◽  
M.I. Walash
Keyword(s):  
Charge Transfer ◽  
Complex Formation ◽  
Charge Transfer Complex ◽  
Chloranilic Acid

scholarly journals DETERMINATION OF TRIMETHOPRIM BY CHARGE-TRANSFER COMPLEX FORMATION

1994 ◽  
Vol 3 (2) ◽  
pp. 132-141
Author(s):  
Mohamed El Balkiny ◽  
Gamal Ragab ◽  
Magda Ayad
Keyword(s):  
Charge Transfer ◽  
Complex Formation ◽  
Charge Transfer Complex

scholarly journals Simple Methods for the Spectrophotometric Determination of Carvedilol

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Divya N. Shetty ◽  
B. Narayana
Keyword(s):  
Charge Transfer ◽  
Complex Formation ◽  
Confidence Level ◽  
Charge Transfer Complex ◽  
Condensation Reaction ◽  
Pharmaceutical Preparations ◽  
Molar Absorptivity ◽  
Spectrophotometric Methods ◽  
Accuracy And Precision

Two simple spectrophotometric methods are described for the determination of carvedilol (CAR). Method A is the condensation reaction of CAR with p-dimethylaminobenzaldehyde (PDAB), and the reaction mixture exhibits maximum absorbance at 601 nm. Method B is based on the charge transfer complex formation of CAR with p-chloranil; the color developed is measured at 662 nm. The calibration graphs are found to be linear over 50.00–250.00 and 20.00–100.0 μg mL−1 with molar absorptivity values of 0.92×103 and 0.257×104 L mol−1cm−1 for CAR-PDAB and CAR-p-chloranil, respectively. Statistical comparisons of the results are performed with regard to accuracy and precision using Student’s t-test and F-test at 95% confidence level. The methods are successfully employed for the determination of CAR in pharmaceutical preparations, and the results agree favorably with the reference and proposed methods.

scholarly journals Two charge-transfer complex spectrophotometric methods for the determination of sulpiride in pharmaceutical formulations

2009 ◽  
Vol 7 (4) ◽  
pp. 870-875 ◽  
Author(s):  
Sayed Zayed
Keyword(s):  
Charge Transfer ◽  
Charge Transfer Complex ◽  
Standard Free Energy ◽  
Pharmaceutical Formulations ◽  
Association Constants ◽  
Official Method ◽  
Chloranilic Acid ◽  
Spectrophotometric Methods ◽  
Charge Transfer Complexation

AbstractTwo simple, rapid, accurate and sensitive spectrophotometric methods are described for the determination of sulpiride. They are based on charge transfer complexation between the drug as n-electron donor and p-chloranilic acid as π acceptor or iodine as σ-acceptor. These give highly coloured complexes with absorption maxima at 518 and 363, 294 nm, respectively. Beer’s law linear ranges were 13.7–341.4 and 1.7–20.5 µg mL−1 for the p-chloranilic acid and iodine methods. The methods were successfully applied to the determination of the drug in Dogmatil® Fort tablets and the results compared with the official method. The complex association constants and standard free energy changes were calculated using Benesi-Hildebrand plots.

Sign in / Sign up

Export Citation Format

Share Document