AbstractTwo simple, rapid, accurate and sensitive spectrophotometric methods are described for the determination of sulpiride. They are based on charge transfer complexation between the drug as n-electron donor and p-chloranilic acid as π acceptor or iodine as σ-acceptor. These give highly coloured complexes with absorption maxima at 518 and 363, 294 nm, respectively. Beer’s law linear ranges were 13.7–341.4 and 1.7–20.5 µg mL−1 for the p-chloranilic acid and iodine methods. The methods were successfully applied to the determination of the drug in Dogmatil® Fort tablets and the results compared with the official method. The complex association constants and standard free energy changes were calculated using Benesi-Hildebrand plots.
The Use of Chloranilic Acid for the Spectrophotometric Determination of Three Macrolides through Charge Transfer Complex
