The effect of cycloheximide on DNA synthesis in cells productively-infected with polyoma virus

Virology ◽  
1970 ◽  
Vol 42 (4) ◽  
pp. 979-992 ◽  
Author(s):  
P.E. Branton ◽  
W.P. Cheevers ◽  
Rose Sheinin
Keyword(s):  
Virology ◽  
1968 ◽  
Vol 36 (4) ◽  
pp. 652-661 ◽  
Author(s):  
P.E. Branton ◽  
Rose Sheinin
Keyword(s):  

Temperature-sensitive mutants of polyoma virus have been examined to determine whether they are able to induce the synthesis of cellular DNA under conditions where viral gene products are defective. Two ‘early’ mutants, and one ‘late’ mutant of polyoma induce cellular DNA synthesis normally under conditions where virus growth is inhibited because viral gene products are defective.


eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Nicholas Chim ◽  
Lynnette N Jackson ◽  
Anh M Trinh ◽  
John C Chaput

High resolution crystal structures of DNA polymerase intermediates are needed to study the mechanism of DNA synthesis in cells. Here we report five crystal structures of DNA polymerase I that capture new conformations for the polymerase translocation and nucleotide pre-insertion steps in the DNA synthesis pathway. We suggest that these new structures, along with previously solved structures, highlight the dynamic nature of the finger subdomain in the enzyme active site.


Virology ◽  
1965 ◽  
Vol 27 (3) ◽  
pp. 262-272 ◽  
Author(s):  
L.H. Hartwell ◽  
M. Vogt ◽  
R. Dulbecco

1974 ◽  
Vol 39 (0) ◽  
pp. 187-198 ◽  
Author(s):  
R. Kamen ◽  
D. M. Lindstrom ◽  
H. Shure ◽  
R. W. Old
Keyword(s):  

1974 ◽  
Vol 24 (1) ◽  
pp. 93-105 ◽  
Author(s):  
J.S. Morgante ◽  
A.B. da Cunha ◽  
C. Pavan ◽  
J.J. Biesele ◽  
R.W. Riess ◽  
...  

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