A review of the dose-response induction of DNA adducts by aflatoxin B1 and its implications to quantitative cancer-risk assessment

1993 ◽  
Vol 296 (3) ◽  
pp. 181-198 ◽  
Author(s):  
Wai Nang Choy
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Dna Adducts ◽  
Dose Response ◽  
Aflatoxin B1 ◽  
Cancer Risk Assessment

scholarly journals Cancer risk assessment: Optimizing human health through linear dose–response models

2015 ◽  
Vol 81 ◽  
pp. 137-140 ◽  
Author(s):  
Edward J. Calabrese ◽  
Dima Yazji Shamoun ◽  
Jaap C. Hanekamp
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Human Health ◽  
Dose Response ◽  
Cancer Risk Assessment ◽  
Response Models ◽  
Linear Dose

Sources of Uncertainty in Dose-Response Modeling of Epidemiological Data for Cancer Risk Assessment

1999 ◽  
Vol 895 (1 UNCERTAINTY I) ◽  
pp. 212-222 ◽  
Author(s):  
LESLIE STAYNER ◽  
A. JOHN BAILER ◽  
RANDALL SMITH ◽  
STEPHEN GILBERT ◽  
FAYE RICE ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Dose Response ◽  
Epidemiological Data ◽  
Cancer Risk Assessment ◽  
Sources Of Uncertainty ◽  
Response Modeling

scholarly journals Hormesis: Implications for Cancer Risk Assessment

Dose-Response ◽  
2005 ◽  
Vol 3 (3) ◽  
pp. dose-response.0 ◽  
Author(s):  
Jonathan Borak ◽  
Greg Sirianni
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Dose Response ◽  
Low Dose ◽  
Cancer Risk Assessment ◽  
Response Curves ◽  
Response Characteristics ◽  
Non Linear ◽  
Dose Responses ◽  
Current Guidelines

Current guidelines for cancer risk assessment emphasize a toxicant's “mode of action”, rather than its empirically derived dose-response relationship, for determining whether linear low-dose extrapolation is appropriate. Thus, for reasons of policy, demonstration of hormesis is generally insufficient to justify a non-linear approach, although it may provide important insights into the actions of toxicants. We evaluated dose-response characteristics of four carcinogens reported to have hormetic dose-response curves: cadmium chloride; ionizing radiation; PAHs; and, 2,3,7,8-TCDD. For each, the study that documented hormesis in one organ also provided evidence of non-hormetic dose-responses in other organs or non-hormetic responses for seemingly similar carcinogens in the same species and organs. Such inconsistency suggests toxicologic reasons that the finding of hormesis alone is not sufficient to justify use of non-linear low-dose extrapolations. Moreover, available data in those examples are not sufficient to know whether hormesis is a property of the toxicants, the target organ, or the exposed species. From the perspectives of cancer risk assessment, the greatest informational value of hormesis may be that it provokes mechanistic studies intended to explain why hormesis occurs.

Cancer risk assessment for 1,3-butadiene: Dose–response modeling from an epidemiological perspective

2007 ◽  
Vol 166 (1-3) ◽  
pp. 140-149 ◽  
Author(s):  
Robert L. Sielken ◽  
Ciriaco Valdez-Flores ◽  
Michael L. Gargas ◽  
Christopher R. Kirman ◽  
M. Jane Teta ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Dose Response ◽  
Cancer Risk Assessment ◽  
Response Modeling

Aflatoxin B1 in walnuts: a probabilistic cancer risk assessment for Iranians

2020 ◽  
Vol 102 (9) ◽  
pp. 506-519 ◽  
Author(s):  
Seyedeh Faezeh Taghizadeh ◽  
Ramin Rezaee ◽  
Hasan Badibostan ◽  
Gholamreza Karimi
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Aflatoxin B1 ◽  
Cancer Risk Assessment
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