Investigation of the dominant-lethal assay. I. Dominant-lethal effects of chemical compounds after long-term administration into male mice

1978 ◽  
Vol 54 (2) ◽  
pp. 242
Author(s):  
M. Masubuchi ◽  
A. Takahashi ◽  
S. Yoshida ◽  
H. Ando ◽  
Y. Kubo ◽  
...  
Keyword(s):  
Chemical Compounds ◽  
Male Mice ◽  
Lethal Effects ◽  
Dominant Lethal ◽  
Term Administration ◽  
Dominant Lethal Assay

scholarly journals The Effects of Long-Term Administration of Methamphetamine on the Cerebellum of the Male Mice: a Stereological Study

2014 ◽  
Vol 2 (4) ◽  
pp. 37-45 ◽  
Author(s):  
Razieh Kamali Ardakani ◽  
Hossein Nahangi ◽  
Maryam Yadegari ◽  
Mohammad Hosseini-Sharifabad ◽  
◽  
...  
Keyword(s):  
Male Mice ◽  
Term Administration

scholarly journals Mutagenicity of DDT in Mice, Drosophila melanogaster and Neurospora crassa

1974 ◽  
Vol 27 (4) ◽  
pp. 427 ◽  
Author(s):  
Julian M Clark
Keyword(s):  
Body Weight ◽  
Acute Treatment ◽  
Chromosome Breakage ◽  
Male Mice ◽  
Lethal Mutations ◽  
Dominant Lethal ◽  
Dominant Lethal Mutations ◽  
Early Spermatid ◽  
Dominant Lethal Assay ◽  
Oral Doses

The pesticide DDT was examined for possible mutagenicity in mice, D. melanogaster and N. crassa. Through the use of the dominant-lethal assay it was found that acute oral doses of DDT (2 x 150 mg/kg body weight) in male mice induced dominant lethal mutations in early spermatid and spermato-cyte stages. Chronic oral doses of DDT (2 x 100 mg/kg body weight per week for 10 weeks) in male mice caused a persistent increase in the number of dominant lethal mutations. Histological sections showed that chronic treatment of mice with DDT caused changes in seminiferous tubule morphology and degeneration of B-type spermatogonia. Acute treatment of mice with DDT caused an increase in spermatocyte chromosome breakage, stickiness and precocious separation of the X and Y bivalent.

scholarly journals Effects of β-glucan polysaccharide revealed by the dominant lethal assay and micronucleus assays, and reproductive performance of male mice exposed to cyclophosphamide

2014 ◽  
Vol 37 (1) ◽  
pp. 111-119 ◽  
Author(s):  
Rodrigo Juliano Oliveira ◽  
João Renato Pesarini ◽  
Maria José Sparça Salles ◽  
Tatiane Yumi Nakamura Kanno ◽  
Ana Carolina dos Santos Lourenço ◽  
...  
Keyword(s):  
Reproductive Performance ◽  
Male Mice ◽  
Dominant Lethal ◽  
Dominant Lethal Assay

Dominant lethal effects of nocodazole in germ cells of male mice

2015 ◽  
Vol 77 ◽  
pp. 101-104 ◽  
Author(s):  
S.M. Attia ◽  
S.F. Ahmad ◽  
R.M. Okash ◽  
S.A. Bakheet
Keyword(s):  
Germ Cells ◽  
Male Mice ◽  
Lethal Effects ◽  
Dominant Lethal
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