Mutagenicity tests of diflubenzuron in the micronucleus test in mice, the L5178Y mouse lymphoma forward mutation assay, and the Ames Salmonella reverse mutation test

1979 ◽  
Vol 66 (1) ◽  
pp. 45-53 ◽  
Author(s):  
James T. Macgregor ◽  
Daniel H. Gould ◽  
Ann D. Mitchell ◽  
MitchellGery P. Sterling
Keyword(s):  
Micronucleus Test ◽  
Reverse Mutation ◽  
Mutagenicity Tests ◽  
Mutation Assay ◽  
Forward Mutation ◽  
Mouse Lymphoma

Responses of the L5178Y tk+/tk− mouse lymphoma cell forward mutation assay ii: 18 coded chemicals

1988 ◽  
Vol 11 (1) ◽  
pp. 91-118 ◽  
Author(s):  
Douglas B. McGregor ◽  
Alison Brown ◽  
Pamela Cattanach ◽  
Ian Edwards ◽  
Douglas McBride ◽  
...  
Keyword(s):  
Lymphoma Cell ◽  
Mutation Assay ◽  
Forward Mutation ◽  
Mouse Lymphoma

scholarly journals In VitroandIn VivoGenotoxicity Assessment ofAristolochia manshuriensisKom.

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Youn-Hwan Hwang ◽  
Taesoo Kim ◽  
Won-Kyung Cho ◽  
Hye Jin Yang ◽  
Dong Hoon Kwak ◽  
...  
Keyword(s):  
Chromosomal Aberration ◽  
Micronucleus Test ◽  
Safety Information ◽  
Chinese Hamster ◽  
Metabolic Activation ◽  
Vehicle Group ◽  
Reverse Mutation ◽  
Significant Difference ◽  
Chromosomal Aberration Test ◽  
Mutation Assay

Arisolochiae speciesplants containing aristolochic acids I and II (AA I and AA II) are well known to cause aristolochic acid nephropathy (AAN). Recently, there are various approaches to use AAs-containing herbs after the removal of their toxic factors. However, there is little information about genotoxicity ofArisolochiae manshuriensisKom. (AMK)per se. To obtain safety information for AMK, its genotoxicity was evaluated in accordance with OECD guideline. To evaluate genotoxicity of AMK, we tested bacterial reverse mutation assay, chromosomal aberration test, and micronucleus test. Here, we also determined the amounts of AA I and II in AMK (2.85 ± 0.08 and 0.50 ± 0.02 mg/g extract, resp.). In bacterial reverse mutation assay, AMK dose-dependently increased revertant colony numbers in TA98, TA100 and TA1537 regardless of metabolic activation. AMK increased the incidence of chromosomal aberration in Chinese hamster ovary-K1 cells, but there was no statistically significant difference. The incidences of micronucleus in bone marrow erythrocyte were significantly increased in mice after oral administration of AMK (5000 mg/kg), comparing with those of vehicle group (P<0.05). The results of three standard tests suggest that the genotoxicity of AMK is directly related to the AAs contents in AMK.

Responses of the l5178y tk+/tk− mouse lymphoma cell forward mutation assay: III. 72 Coded chemicals

1988 ◽  
Vol 12 (1) ◽  
pp. 85-154 ◽  
Author(s):  
Douglas B. McGregor ◽  
Alison Brown ◽  
Pamela Cattanach ◽  
Ian Edwards ◽  
Douglas McBride ◽  
...  
Keyword(s):  
Lymphoma Cell ◽  
Mutation Assay ◽  
Forward Mutation ◽  
Mouse Lymphoma
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