Recombinogenic and mutagenic effects of the antitumour antibiotic bleomycin in Aspergillus nidulans

1982 ◽  
Vol 102 (1) ◽  
pp. 51-57 ◽  
Author(s):  
N.A. Demopoulos ◽  
A. Kappas ◽  
M. Pelecanos
Keyword(s):  
Aspergillus Nidulans ◽  
Mutagenic Effects

Mutagenic effects of the herbicide 3′,4′-dichloropropionanilide and its degradation products

1970 ◽  
Vol 16 (5) ◽  
pp. 369-372 ◽  
Author(s):  
Ishwari Prasad
Keyword(s):  
Aspergillus Nidulans ◽  
Benzene Ring ◽  
Mutation Frequency ◽  
Degradation Products ◽  
Para Position ◽  
Ortho Position ◽  
Back Mutation ◽  
Mutagenic Effects

3′,4′-Dichloropropionanilide; its biodegradation products 3,4-dichloroaniline and 3,3′,4,4′-tetrachloroazobenzene; and related chloroaniline and chlorobenzenes were tested for effects on the back mutation frequency of the meth3 locus in Aspergillus nidulans. 3,4-Dichloroaniline was more mutagenic than 3,3′,4,4′-tetrachloroazobenzene and 3′,4′-dichloropropionanilide. Chlorine in the para position on benzene ring increased mutagenicity more than chlorine in the meta or ortho position. Chloroaniline was more mutagenic than the corresponding dichlorobenzene.

Spinal meningioma after treatment for Hodgkin disease

2001 ◽  
Vol 95 (2) ◽  
pp. 232-235 ◽  
Author(s):  
Andrew J. Martin ◽  
Christopher J. Hammond ◽  
H. Jane Dobbs ◽  
Safa Al-Sarraj ◽  
Nicholas W. M. Thomas
Keyword(s):  
Hodgkin Disease ◽  
Second Primary ◽  
Combined Modality Treatment ◽  
Spinal Meningioma ◽  
Primary Tumors ◽  
Content Type ◽  
Radiation Induced ◽  
Mutagenic Effects ◽  
Long Term Survivors

✓ Long-term survivors of Hodgkin disease may develop second primary tumors caused by the mutagenic effects of radio- and chemotherapy. The authors describe the case of a 35-year-old woman who presented with an unusual meningioma of the cervical spine 9 years after undergoing combined-modality treatment for Hodgkin disease. To the authors' knowledge, this is the first report of spinal meningioma as a complication of such therapy. Whereas radiation-induced intracranial meningiomas are well described in the literature, treatment-induced meningiomas of the spine have not been widely recognized.

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