Interaction of acute feline herpesvirus-1 and chronic feline immunodeficiency virus infections in experimentally infected specific pathogen free cats

1992 ◽  
Vol 35 (1-2) ◽  
pp. 95-119 ◽  
Author(s):  
Gerhard H. Reubel ◽  
Jeanne W. George ◽  
Jeffrey E. Barlough ◽  
Joanne Higgins ◽  
Chris K. Grant ◽  
...  
Keyword(s):  
Feline Immunodeficiency Virus ◽  
Specific Pathogen Free ◽  
Virus Infections ◽  
Immunodeficiency Virus ◽  
Feline Herpesvirus ◽  
Specific Pathogen ◽  
Herpesvirus 1

scholarly journals Experimental Mucosal Infection with Molecularly Cloned Feline Immunodeficiency Viruses

2003 ◽  
Vol 10 (1) ◽  
pp. 185-188 ◽  
Author(s):  
Mariko Kohmoto ◽  
Yasuhiro Ikeda ◽  
Eiji Sato ◽  
Yorihiro Nishimura ◽  
Yasuo Inoshima ◽  
...  
Keyword(s):  
Virus Strain ◽  
Feline Immunodeficiency Virus ◽  
Deletion Mutant ◽  
Cell Tropism ◽  
Specific Pathogen Free ◽  
Mucosal Epithelium ◽  
Immunodeficiency Virus ◽  
Mucosal Infection ◽  
Specific Pathogen

ABSTRACT Four of six specific pathogen-free cats were infected after intravaginal exposure to molecularly cloned lymphotropic but non-Crandell feline kidney (CRFK)-tropic feline immunodeficiency virus strain TM2 and its AP-1 deletion mutant. The sequences of the env V3-to-V5 region which defines the CRFK tropism were unchanged in the infected cats through the infection. These data suggest that the strain was transmitted across the mucosal epithelium without a broadening of cell tropism.

scholarly journals Molecularly cloned feline immunodeficiency virus NCSU1 JSY3 induces immunodeficiency in specific-pathogen-free cats.

1996 ◽  
Vol 70 (5) ◽  
pp. 3011-3017 ◽  
Author(s):  
J S Yang ◽  
R V English ◽  
J W Ritchey ◽  
M G Davidson ◽  
T Wasmoen ◽  
...  
Keyword(s):  
Feline Immunodeficiency Virus ◽  
Specific Pathogen Free ◽  
Immunodeficiency Virus ◽  
Specific Pathogen

scholarly journals Histologic Classification and Immunophenotype of Lymphosarcomas in Cats with Naturally and Experimentally Acquired Feline Immunodeficiency Virus Infections

1996 ◽  
Vol 33 (3) ◽  
pp. 264-272 ◽  
Author(s):  
J. J. Callanan ◽  
B. A. Jones ◽  
J. Irvine ◽  
B. J. Willett ◽  
I. A. P. McCandlish ◽  
...  
Keyword(s):  
B Cell ◽  
Feline Immunodeficiency Virus ◽  
Cell Activation ◽  
Polyclonal Antibodies ◽  
Leukemia Virus ◽  
Feline Leukemia Virus ◽  
B Cell Activation ◽  
Virus Infections ◽  
Histologic Classification ◽  
Immunodeficiency Virus

Lymphosarcoma (malignant lymphoma) is the commonest hematopoietic tumor in the cat. Many cases are associated with feline leukemia virus (FeLV) infection, but epidemiologic and experimental data suggest that feline immunodeficiency virus (FIV) may also have a role in lymphomagenesis. In this paper, we describe the clinical presentation, histologic classification, and immunophenotype of lymphosarcoma in eight domestic cats with natural or experimental FIV infections. The tumors were often of unusual distribution, with the majority of cases conforming to the least common anatomic classification of “miscellaneous.” Histopathologic and immunophenotypic analysis using a panel of anti-cat and cross-reactive anti-human monoclonal and polyclonal antibodies identified seven of these tumors as high-grade B cell lymphomas of the centroblastic or immunoblastic subtypes. The remaining case was a T-cell tumor associated with a concurrent FeLV infection. Our findings, together with the results of an analysis of FIV proviral DNA in these tumors, indicate that the B-cell lymphosarcomas were comparable to those observed in human and simian immunodeficiency virus infections and that the role of FIV in lymphomagenesis is indirect and related to the potential for malignant transformation during polyclonal B cell activation.

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