6-Hydroxydopamine lesion of the rat prefrontal cortex increases locomotor activity, impairs acquisition of delayed alternation tasks, but does not affect uninterrupted tasks in the radial maze

1990 ◽  
Vol 37 (2) ◽  
pp. 157-168 ◽  
Author(s):  
Michael Bubser ◽  
Werner J. Schmidt
Keyword(s):  
Prefrontal Cortex ◽  
Locomotor Activity ◽  
Radial Maze ◽  
Delayed Alternation ◽  
6 Hydroxydopamine

scholarly journals Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
K. Slack ◽  
R. Billing ◽  
S. Matthews ◽  
H. N. Allbutt ◽  
R. Einstein ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Locomotor Activity ◽  
Core Body Temperature ◽  
Diurnal Rhythms ◽  
Sensorimotor Function ◽  
Cardiovascular Autonomic Dysfunction ◽  
Sham Surgery ◽  
6 Hydroxydopamine ◽  
Core Body

The present study evaluated whether the unilateral 6-hydroxydopamine (6-OHDA) model of Parkinson's disease produces autonomic deficits. Autonomic parameters were assessed by implanting a small radiofrequency telemetry device which measured heart rate variability (HRV), diurnal rhythms of heart rate (HR), core body temperature (cBT) and locomotor activity (LA). Rats then received 6-OHDA lesion or sham surgery. 6-OHDA lesioned rats exhibited head and body axis biases, defective sensorimotor function (“disengage” test), and prominent apomorphine rotation (allP<.05versus controls). Diurnal rhythm of HR was lower for 6-OHDA lesioned rats (n=8) versus controls (n=6;P<.05). Whilst HR decreased similarly in both groups during the day, there was a greater decrease in HR for the 6-OHDA lesioned rats at night (by 38 b.p.m. relative to 17 b.p.m. for controls). LA and cBT did not differ between surgery groups. This study indicates the unilateral 6-OHDA model of PD shows subtle signs of cardiovascular autonomic dysfunction.

Left and right 6-hydroxydopamine lesions of the medial prefrontal cortex differentially affect voluntary ethanol consumption

1999 ◽  
Vol 823 (1-2) ◽  
pp. 59-66 ◽  
Author(s):  
Darci M Nielsen ◽  
Kathleen J Crosley ◽  
Richard W Keller ◽  
Stanley D Glick ◽  
Jeffrey N Carlson
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Ethanol Consumption ◽  
Left And Right ◽  
6 Hydroxydopamine ◽  
Voluntary Ethanol Consumption
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