Primary afferent-evoked slow EPSPS and responses to substance P of dorsal horn neurons in the adult rat spinal cord slices

1992 ◽  
Vol 37 ◽  
pp. S183 ◽  
Author(s):  
M. Yoshimura ◽  
T. Shimizu ◽  
H. Inokuchi ◽  
S. Nishi
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Dorsal Horn ◽  
Rat Spinal Cord ◽  
Primary Afferent ◽  
Adult Rat ◽  
Dorsal Horn Neurons ◽  
Adult Rat Spinal Cord

Primary afferent-evoked slow EPSPs and responses to substance P of dorsal horn neurons in the adult rat spinal cord slices

1993 ◽  
Vol 46 (1-2) ◽  
pp. 407-409 ◽  
Author(s):  
Megumu Yoshimura ◽  
Toko Shimizu ◽  
Yohichi Yajiri ◽  
Hiroe Inokuchi ◽  
Syogoro Nishi
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Dorsal Horn ◽  
Rat Spinal Cord ◽  
Primary Afferent ◽  
Adult Rat ◽  
Dorsal Horn Neurons ◽  
Adult Rat Spinal Cord

A-fiber sensory input induces neuronal cell death in the dorsal horn of the adult rat spinal cord

2001 ◽  
Vol 435 (3) ◽  
pp. 276-282 ◽  
Author(s):  
Richard E. Coggeshall ◽  
Helena A. Lekan ◽  
Fletcher A. White ◽  
Clifford J. Woolf
Keyword(s):  
Spinal Cord ◽  
Cell Death ◽  
Dorsal Horn ◽  
Sensory Input ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Rat Spinal Cord ◽  
Adult Rat ◽  
Adult Rat Spinal Cord

Actions of Midazolam on Excitatory Transmission in Dorsal Horn Neurons of Adult Rat Spinal Cord

2006 ◽  
Vol 104 (2) ◽  
pp. 338-343 ◽  
Author(s):  
Tatsuro Kohno ◽  
Ayako Wakai ◽  
Toyofumi Ataka ◽  
Miho Ikoma ◽  
Tomohiro Yamakura ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Benzodiazepine Receptor ◽  
Gamma Aminobutyric Acid ◽  
Excitatory Postsynaptic Currents ◽  
Adult Rat ◽  
Dorsal Horn Neurons ◽  
Postsynaptic Currents ◽  
Excitatory Transmission ◽  
Adult Rat Spinal Cord

Background Although intrathecal administration of midazolam, a water-soluble imidazobenzodiazepine derivative, has been found to produce analgesia, how it exerts this effect at the neuronal level in the spinal cord is not fully understood. Methods The effects of midazolam on electrically evoked and spontaneous excitatory transmission were examined in lamina II neurons of adult rat spinal cord slices using the whole cell patch clamp technique. Results Bath-applied midazolam (1 microm) diminished Adelta- and C-fiber evoked polysynaptic excitatory postsynaptic currents in both amplitude and integrated area. However, it affected neither Adelta- and C-fiber evoked monosynaptic excitatory postsynaptic currents in amplitude nor miniature excitatory postsynaptic currents in amplitude, frequency, and decay time constant. In the presence of a benzodiazepine receptor antagonist, flumazenil (5 microm), midazolam (1 microm) did not diminish Adelta-fiber evoked polysynaptic excitatory postsynaptic currents, suggesting that midazolam modulate the gamma-aminobutyric acid interneurons in the dorsal horn. Conclusions Midazolam reduced excitatory synaptic transmission by acting on the gamma-aminobutyric acid type A/benzodiazepine receptor in interneurons, leading to a decrease in the excitability of spinal dorsal horn neurons. This may be a possible mechanism for the antinociception by midazolam in the spinal cord.

Visualization of lamina I of the dorsal horn in live adult rat spinal cord slices

2000 ◽  
Vol 96 (2) ◽  
pp. 133-142 ◽  
Author(s):  
Nadège Chéry ◽  
Xiao Hong Yu ◽  
Yves De Koninck
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Rat Spinal Cord ◽  
Adult Rat ◽  
Lamina I ◽  
Adult Rat Spinal Cord

Alterations in primary afferent input to substantia gelatinosa of adult rat spinal cord after neonatal capsaicin treatment

2003 ◽  
Vol 74 (6) ◽  
pp. 928-933 ◽  
Author(s):  
Kun Yang ◽  
Hidemasa Furue ◽  
Tsugumi Fujita ◽  
Eiichi Kumamoto ◽  
Megumu Yoshimura
Keyword(s):  
Spinal Cord ◽  
Afferent Input ◽  
Substantia Gelatinosa ◽  
Rat Spinal Cord ◽  
Primary Afferent ◽  
Adult Rat ◽  
Adult Rat Spinal Cord

Role of Aδ afferent fibers in modulation of primary afferent input to the adult rat spinal cord

1995 ◽  
Vol 691 (1-2) ◽  
pp. 92-98 ◽  
Author(s):  
T. Shimizu ◽  
M. Yoshimura ◽  
H. Baba ◽  
K. Shimoji ◽  
H. Higashi
Keyword(s):  
Spinal Cord ◽  
Afferent Input ◽  
Rat Spinal Cord ◽  
Primary Afferent ◽  
Adult Rat ◽  
Afferent Fibers ◽  
Adult Rat Spinal Cord
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