Isolation and characterization of a growth inhibitory factor from hamster liver

1994 ◽  
Vol 1220 (2) ◽  
pp. 107-117 ◽  
Author(s):  
Chieko Hashimoto ◽  
Masako Ayaki ◽  
Yukiharu Inui
Keyword(s):  
Inhibitory Factor ◽  
Growth Inhibitory Factor ◽  
Isolation And Characterization ◽  
Growth Inhibitory

Identification and characterization of a T cell growth inhibitory factor produced by K562 erythromyeloid cells

1991 ◽  
Vol 138 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Mario De Felice ◽  
Heather M. Bond ◽  
Rosa Pizzano ◽  
Maria Caterina Turco ◽  
Giuliana Valerio ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Growth ◽  
Inhibitory Factor ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory ◽  
T Cell Growth ◽  
Identification And Characterization

scholarly journals Could a Growth Inhibitory Factor, Present Only during Pregnancy, be Made Available to Treat Cancer in Adults? A Commentary

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Mizejewski GJ
Keyword(s):  
Fetal Growth ◽  
Therapeutic Agent ◽  
Germ Cell Tumors ◽  
Inhibitory Factor ◽  
Additional Function ◽  
Major Function ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory ◽  
Age Dependent ◽  
Growth Promoting

Human alpha-fetoprotein (AFP) is well-known as the “gold standard” biomarker for liver and germ cell tumors. It has also been utilized as a pregnancy screening analyte for neural tube defects as well as Down syndrome, when combined with other gestational-age dependent biomarkers. However, a lesser known and recognized property of AFP is its role in the maintenance and monitoring of fetal growth during ontogenetic development in man. Although a major function of AFP during pregnancy involves the serum transport of estrogens, fatty acids, retinoid, and other compounds, the positive and negative regulation of fetal growth is a vital additional function of AFP. Human AFP largely functions as a growth promoting agent; however, the fetal protein is able to temporarily convert to a growth inhibitory factor in stress and shock environments in the fetal milieu. The development of a transient form of AFP or its derived peptides could be harnessed for use as an adjunct therapeutic agent to treat cancer in adults.

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