Ambulatory blood pressure monitoring and circadian variation of cardiovascular disease; clinical and research applications

1992 ◽  
Vol 36 (2) ◽  
pp. 135-149 ◽  
Author(s):  
Henry J. Purcell ◽  
J.Simon R. Gibbs ◽  
Andrew J.S. Coats ◽  
Kim M. Fox
1991 ◽  
Vol 37 (10) ◽  
pp. 1880-1884 ◽  
Author(s):  
M A Weber ◽  
D H Smith ◽  
J M Neutel ◽  
D G Cheung

Abstract Traditionally, blood pressure has been measured by the sphygmomanometer in the medical office. There is growing evidence, however, that office blood pressures may not be typical of values throughout the day. Between 20% and 30% of patients diagnosed with hypertension in the office actually are normotensive at other times. Ambulatory blood pressure monitoring with small, portable devices that automatically measure blood pressure every few minutes throughout the day appears to be an appropriate tool when "white-coat" hypertension is suspected--i.e., for individuals whose hypertension in the physician's office is not associated with other physical or historical evidence for cardiovascular disease or with other risk factors. Used prudently, ambulatory monitoring is a cost-effective technique that potentially can prevent unnecessary treatment of patients. Moreover, whole-day measurements may correlate more closely than office measurements may correlate more closely than office measurements do with findings of cardiovascular disease. This new approach also has highlighted the circadian pattern of blood pressure, especially the sharp early to mid-morning increase that coincides with an increased tendency to major cardiovascular events. This has focused attention on directing antihypertensive therapy towards the morning hours. Ambulatory monitoring is now used routinely in studies of antihypertensive drugs. This technique has no placebo effect and takes fewer patients to assess drug efficacy than do conventional methods.


2021 ◽  
Vol 06 (02) ◽  
pp. 079-085
Author(s):  
Ghizal Fatima ◽  
Ashish Jha ◽  
Mohsin Ali Khan

Abstract Background Shift work is associated with behavioral, psychosocial, and physiological consequences in the body that may cause cardiovascular disease (CVD) risk. Therefore, in this study we tried to demonstrate the disruption in circadian rhythm of blood pressure by ambulatory blood pressure monitor in shift working nurses. Methods A total of 50 nurses, 25 night shift working nurses (NSWN), and 25 day shift working nurses (DSWN) underwent ambulatory blood pressure monitoring (ABPM) for a period of 24 hours. Along with measurements of inflammatory markers (hs-CRP and IL-6) the risk factors for cardiovascular disease between NSWN and DSWN and their possible relationship with disrupted circadian rhythm were measured by circadian rhythm questionnaire. Results The mean systolic and diastolic pressure for a period of 24 hours and mean diastolic blood pressure analysis throughout the sleep time was found greater in the NSWN than the DSWN (118 mm Hg vs. 112 mm Hg, p < 0.05: 72 mm Hg vs. 68 mm Hg, p < 0.05: 62 mm Hg vs. 59 mm Hg, p < 0.05). High mean blood pressure readings were found to be more frequent in the NSWN (p < 0.05) than in DSWN. No significant differences were found in IL-6 and hs-CRP levels. However, a significant difference in circadian rhythm abnormality was found in NSWN than in DSWN. Conclusion The 7 day/24 hours ambulatory blood pressure monitoring (ABPM) in NSWN showed a reduced circadian rhythm variation in blood pressure along with abnormality in circadian rhythm itself as compared with DSWN. Work schedules and the consequent rest–activity schedules affect circadian rhythms, with likely long-term impact on health. Therefore, working in critical care unit during night hours leads to abnormal blood pressure in NSWN, suggesting that this type of work, in which sleep is disturbed, leading to mental stress, could be a direct risk factor in cardiovascular diseases.


2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Kazuo Eguchi

Diabetes mellitus and obesity are both related to the risk of cardiovascular disease and sudden death. In hypertensive guidelines, diabetes and obesity, especially abdominal obesity, are regarded as high-risk factors. Ambulatory blood pressure monitoring (ABPM) is an established method for the management of hypertension. However, ABPM is not a standard tool for the management of hypertension in diabetes and obesity. In this paper, recent data on the use of ABPM in diabetes and obesity will be discussed. In patients with diabetes, the ambulatory BP level has been shown to be better than clinic BP in predicting cardiovascular events. A riser pattern has been associated with increased risk of cardiovascular disease. White-coat hypertension and masked hypertension in diabetics constitute a moderate risk. A nondipping pattern is very common in obese hypertensive patients. In this paper, we will summarize the findings on the use of ABPM in patients with diabetes and obesity.


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