New acellular anti-pertussis vaccine; pertussis toxin protein engineering; filamentous hemagglutinin and 69 kDa protein production by Bordetella pertussis deletion mutant

Vaccine ◽  
1992 ◽  
Vol 10 (8) ◽  
pp. 559
Keyword(s):  
Protein Engineering ◽  
Pertussis Vaccine ◽  
Pertussis Toxin ◽  
Bordetella Pertussis ◽  
Deletion Mutant ◽  
Protein Production ◽  
Filamentous Hemagglutinin ◽  
Toxin Protein

scholarly journals Changes in genetic diversity of the Bordetella pertussis population in Serbia between 1953 and 2011

2014 ◽  
Vol 66 (1) ◽  
pp. 107-116 ◽  
Author(s):  
Tatjana Pljesa ◽  
Qiushui He ◽  
Gordana Dakic ◽  
Mirjana Vignjevic-Krastavcevic ◽  
Nevenka Mikovic ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Pertussis Vaccine ◽  
Vaccination Coverage ◽  
Pertussis Toxin ◽  
Bordetella Pertussis ◽  
Bacterial Population ◽  
Mass Vaccination ◽  
Whole Cell

Mass vaccination has significantly reduced the incidence of pertussis, however, the disease is re-emerging, even in some countries with high vaccination coverage. In Serbia, whole cell pertussis vaccine was introduced in 1957. To monitor changes in bacterial population, 77 isolates collected from 1953 to 2011 were studied. The methods included serotyping of fimbriae (Fim), genotyping of pertactin (prn) and pertussis toxin S1 subunit (ptxA). A shift from ptxA2 to ptxA1 has been observed in isolates since the late of 1960s. In the period 1961-1979, the genotype ptxA1 became as common as genotype ptxA2. After that, during the period 1980-1989, the predominant ptx genotype was ptxA1. The reappearance of the ptxA2 allele followed an addition of the two strains harboring ptxA1 in the vaccine in 1985. The allele prn1 was predominant among the Serbian isolates, though prn3 and prn11 have been detected since 1981. The prn2 allele was only found in one strain isolated in 1984, two of the four strains isolated in 2000 and in three isolated strains from 2011. Serotype Fim2.3 disappeared before 1980 and serotype Fim2 became predominant thereafter. The results of this study indicate that the B. pertussis population in Serbia is different from other vaccinated populations and that this difference may be related to the vaccine used.

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