Chromosomal Abnormalities in Dupuytren’s Contracture and Carpal Tunnel Syndrome

1992 ◽  
Vol 17 (3) ◽  
pp. 349-355 ◽  
Author(s):  
A. V. BONNICI ◽  
F. BIRJANDI ◽  
J. D. SPENCER ◽  
S. P. FOX ◽  
A. C. BERRY
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Cell Cultures ◽  
Carpal Tunnel ◽  
Chromosomal Abnormalities ◽  
Dupuytren’S Contracture ◽  
Palmar Fascia ◽  
Dupuytren's Contracture ◽  
Flexor Retinaculum ◽  
Tunnel Syndrome ◽  
Palmar Skin

The cytogenetics of cell cultures derived from Dupuytren’s tissue, adjacent palmar fascia and palmar skin from patients undergoing fasciectomy have been examined and the results compared to cell cultures established from palmar fascia, flexor retinaculum and palmar skin of patients undergoing carpal tunnel decompression. Chromosomal abnormalities were detected in cell cultures from Dupuytren’s tissue in eight of the nine patients studied. Clones of cells trisomic for chromosome 8 were found in five of the nine patients. Trisomy 8 was also present in two of five flexor retinaculum cultures from carpal tunnel syndrome cases. These findings in both Dupuytren’s contracture and carpal tunnel syndrome suggest the presence of chromosomal instability in the palmar fascia. The significance of the chromosomal abnormalities is however unclear, but they indicate a possible common pathway in the onset of pathological fibrosis.

Hand Abnormalities Associated with Non-Insulin-Dependent Diabetes Mellitus in Japan

Hand Surgery ◽  
1997 ◽  
Vol 02 (02) ◽  
pp. 117-122
Author(s):  
Takuro Wada ◽  
Yasuhiko Minagi ◽  
Takashi Kirita ◽  
Seiichi Ishii
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Dependent Diabetes Mellitus ◽  
Diabetic Patients ◽  
Dupuytren’S Contracture ◽  
Joint Mobility ◽  
Limited Joint Mobility ◽  
Dupuytren's Contracture ◽  
Tunnel Syndrome ◽  
Flexor Tenosynovitis

We carried out a survey of hand abnormalities in 65 Japanese adult diabetics (non-insulin-dependent diabetes mellitus) and compared the result with that of 65 non-diabetic adults as controls. A significantly higher incidence of Dupuytren's contracture, limited joint mobility, carpal tunnel syndrome, and flexor tenosynovitis was found in the diabetic group. In the diabetic group, Dupuytren's contracture was noted in 10 patients (15%), limited joint mobility in 34 patients (52%), carpal tunnel syndrome in 21 patients (32%), and flexor tenosynovitis in 10 patients (15%). Dupuytren's contracture in the diabetic patients involved the fourth and fifth rays. In diabetic carpal tunnel syndrome, as compared to the idiopathic form, men were more frequently affected than women. Carpal tunnel syndrome showed a positive correlation with duration of the diabetes and use of insulin during the last twelve months prior to the examination. All of 10 diabetic patients with flexor tenosynovitis also had limited joint mobility. Six of these 10 patients also had carpal tunnel syndrome.

scholarly journals The Musculoskeletal Disorders in Diabetic Patients and the Evaluation of their Relationship with Metabolic Parameters and Microvascular Complications

2021 ◽  
Author(s):  
Pelin Edis ◽  
Nilufer Ozdemir ◽  
Zeliha Hekimsoy
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Musculoskeletal Disorders ◽  
Carpal Tunnel ◽  
Adhesive Capsulitis ◽  
Microvascular Complications ◽  
Metabolic Parameters ◽  
Diabetic Patients ◽  
Dupuytren’S Contracture ◽  
Dupuytren's Contracture ◽  
Tunnel Syndrome

Background: Diabetes mellitus has been associated with many different musculoskeletal system problems. Objective: This study aims to show the prevalence of musculoskeletal disorders in patients with diabetes and to reveal their relationship to the metabolic parameters and microvascular complications. Methods: Seven hundred two diabetic patients who consecutively applied to our clinic between March 2017 and February 2018 were included in this prospective cross-sectional study. The relationship of the musculoskeletal disorders including carpal tunnel syndrome, Dupuytren’s contracture, adhesive capsulitis, flexor tenosynovitis, limited joint mobility syndrome, Charcot arthropathy, diabetic foot and gout to the patients’ age, gender, type of diabetes, duration of diabetes, metabolic parameters, and microvascular complications were evaluated. Results: Musculoskeletal system disorders were detected in 45.9% (n = 322) of the 702 diabetic patients evaluated in our study. The most common disorders were carpal tunnel syndrome 17.7% (n = 124), Dupuytren’s contracture 14.4% (n = 101), and adhesive capsulitis 13.8% (n = 97). A statistically significant relationship of the HbA1c level with Dupuytren’s contracture, carpal tunnel syndrome, and adhesive capsulitis was detected (p<0.05). Conclusions: Patients’ age, duration of diabetes, HbA1c level, and presence of microvascular complications are associated with musculoskeletal disorders in this population.

scholarly journals Incidental finding of a persistent median artery (palmar type) during a routine carpal tunnel decompression: a case report

2017 ◽  
Vol 99 (7) ◽  
pp. e204-e205
Author(s):  
J Butt ◽  
AK Ahluwalia ◽  
A Dutta
Keyword(s):  
Case Report ◽  
Carpal Tunnel Syndrome ◽  
Median Nerve ◽  
Carpal Tunnel ◽  
Incidental Finding ◽  
Surgical Decompression ◽  
Iatrogenic Injury ◽  
Palmar Fascia ◽  
Tunnel Syndrome ◽  
Median Artery

Carpal tunnel syndrome is characterised by compression of the median nerve. The mainstay of treatment is surgical decompression. This case report highlights the occurrence of a persistent median artery, which could complicate surgery. A 55-year-old woman underwent carpal tunnel decompression. An incidental finding of a large-calibre persistent median artery, which was superficial to the flexor sheath, could have been damaged. This was carefully retracted and the procedure was completed, without any complications. Several studies have shown the prevalence of persistent median artery to range from 1.1–27.1%. It is usually found deep to the flexor retinaculum but in this case it was found to be just beneath the palmar fascia. There is increased chance of iatrogenic injury with this particular variant. Surgeons performing the procedure should be mindful of this variation, because accidental damage could result in devastating consequences to the hand.

Lysyl Oxidase Activity in the Cells of Flexor Retinaculum of Individuals With Carpal Tunnel Syndrome

2000 ◽  
Vol 42 (6) ◽  
pp. 582-587 ◽  
Author(s):  
Kallol K. Bose ◽  
Joana Chakraborty ◽  
Sadik Khuder ◽  
William H. Smith-Mensah ◽  
John Robinson
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Oxidase Activity ◽  
Lysyl Oxidase ◽  
Flexor Retinaculum ◽  
Tunnel Syndrome

scholarly journals Anomalous Flexor Digitorum Superficialis Muscle Transposition for Vascular Coverage of the Median Nerve in Recurrent Carpal Tunnel Syndrome

2005 ◽  
Vol 13 (1) ◽  
pp. 27-30
Author(s):  
Michael W Neumeister ◽  
Arian Mowlavi ◽  
Robert C Russell ◽  
Bradon J Wilhelmi
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Median Nerve ◽  
Carpal Tunnel ◽  
Excellent Result ◽  
Vascular Supply ◽  
Flexor Digitorum Superficialis ◽  
Palmar Fascia ◽  
Anomalous Muscle ◽  
Tunnel Syndrome ◽  
Flexor Digitorum

Recurrent carpal tunnel syndrome is uncommon yet troublesome. Significant adhesions and scarring around the median nerve can render it relatively ischemic. A number of vascular flaps have been described to provide vascular coverage in attempts to decrease further cicatricial adhesions and to improve local blood supply around the median nerve. A rare case of an anomalous muscle in the distal forearm used as tissue to provide good vascularized coverage of the median nerve that was severely scarred in its bed is reported. The anomalous muscle was distal to the flexor digitorum superficialis tendon and inserted in the palmar fascia on the ulnar aspect of the hand. Referring branches from the ulnar artery provided vascular supply to the anomalous muscle. The muscle on these vascular pedicles was transposed over the median nerve, providing good, stable, unscarred coverage. The patient had an excellent result with resolution of the carpal tunnel symptoms. The redundant anomalous muscle provided a unique vascularized source for coverage of the median nerve in recurrent carpal tunnel syndrome.

INVESTIGATION OF SEGMENTAL CARPAL TUNNEL PRESSURE IN PATIENTS WITH IDIOPATHIC CARPAL TUNNEL SYNDROME — IS IT NECESSARY TO RELEASE THE DISTAL APONEUROTIC PORTION OF THE FLEXOR RETINACULUM IN ENDOSCOPIC CARPAL TUNNEL RELEASE SURGERY?

Hand Surgery ◽  
2007 ◽  
Vol 12 (03) ◽  
pp. 205-209 ◽  
Author(s):  
Keiichi Murata ◽  
Hiroshi Yajima ◽  
Naoki Maegawa ◽  
Koji Hattori ◽  
Yoshinori Takakura
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Guide Wire ◽  
Carpal Tunnel Release ◽  
Endoscopic Carpal Tunnel Release ◽  
Flexor Retinaculum ◽  
Before And After ◽  
Idiopathic Carpal Tunnel Syndrome ◽  
Tunnel Syndrome ◽  
Carpal Tunnel Release Surgery

Segmental carpal tunnel pressure was measured in 12 hands of 11 idiopathic carpal tunnel syndrome patients before and after two-portal endoscopic carpal tunnel release. We aimed to determine at which part of the carpal tunnel the median nerve could be compressed, and to evaluate whether carpal tunnel pressure could be reduced sufficiently at all segments of the carpal tunnel after the surgery. Pressure measurements were performed using a pressure guide wire. The site with the highest pressure corresponded to the area around the hamate hook; the pressure in the area distal to the flexor retinaculum could be pathogenically high (more than 30 mmHg) before the surgery. The two-portal endoscopic carpal tunnel release achieved sufficient pressure reduction in all segments of the carpal tunnel when the flexor retinaculum and the fibrous structure between the flexor retinaculum and the palmar aponeurosis were completely released.

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