A new model for liver regeneration based on a putative hepatocyte growth inhibitory factor (HGIF): Predicting the initiation, growth, and termination phases

Hepatology ◽  
1995 ◽  
Vol 22 (4) ◽  
pp. A509
Author(s):  
T WHITEHEAD
Keyword(s):  
Liver Regeneration ◽  
Inhibitory Factor ◽  
New Model ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory ◽  
Hepatocyte Growth

scholarly journals Hepatocyte growth inhibitory factor derived from HTLV-I(+) T-cell line is identical to IL-6

1999 ◽  
Vol 23 (5) ◽  
pp. 489-497
Author(s):  
Yasuhiro Kawai ◽  
Akira Yamauchi ◽  
Hajime Nakamura ◽  
Yoshiaki Nakamura ◽  
Tetsuro Hirose ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Line ◽  
Inhibitory Factor ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory ◽  
Hepatocyte Growth

scholarly journals Hepatocyte growth inhibitory factor derived from HTLV-I(+) T cell line is identical to IL-6

1998 ◽  
Vol 114 ◽  
pp. A1153
Author(s):  
Y. Kawai ◽  
A. Yamauchi ◽  
H. Nakamura ◽  
T. Inamoto ◽  
Y. Yamaoka
Keyword(s):  
T Cell ◽  
Cell Line ◽  
Inhibitory Factor ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory ◽  
Hepatocyte Growth

scholarly journals Could a Growth Inhibitory Factor, Present Only during Pregnancy, be Made Available to Treat Cancer in Adults? A Commentary

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Mizejewski GJ
Keyword(s):  
Fetal Growth ◽  
Therapeutic Agent ◽  
Germ Cell Tumors ◽  
Inhibitory Factor ◽  
Additional Function ◽  
Major Function ◽  
Growth Inhibitory Factor ◽  
Growth Inhibitory ◽  
Age Dependent ◽  
Growth Promoting

Human alpha-fetoprotein (AFP) is well-known as the “gold standard” biomarker for liver and germ cell tumors. It has also been utilized as a pregnancy screening analyte for neural tube defects as well as Down syndrome, when combined with other gestational-age dependent biomarkers. However, a lesser known and recognized property of AFP is its role in the maintenance and monitoring of fetal growth during ontogenetic development in man. Although a major function of AFP during pregnancy involves the serum transport of estrogens, fatty acids, retinoid, and other compounds, the positive and negative regulation of fetal growth is a vital additional function of AFP. Human AFP largely functions as a growth promoting agent; however, the fetal protein is able to temporarily convert to a growth inhibitory factor in stress and shock environments in the fetal milieu. The development of a transient form of AFP or its derived peptides could be harnessed for use as an adjunct therapeutic agent to treat cancer in adults.

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