Tumor formation by SV40-immortalized human mammary epithelial cells

1991 ◽  
Vol 27 ◽  
pp. S30
Author(s):  
Aysim Ceyhan ◽  
Irene Garcia ◽  
Harald Lahm ◽  
Bernard Sordat ◽  
Magali Schreyer ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Tumor Formation ◽  
Mammary Epithelial ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial

scholarly journals c-Myc Transforms Human Mammary Epithelial Cells through Repression of the Wnt Inhibitors DKK1 and SFRP1

2007 ◽  
Vol 27 (14) ◽  
pp. 5135-5146 ◽  
Author(s):  
Victoria H. Cowling ◽  
Celina M. D'Cruz ◽  
Lewis A. Chodosh ◽  
Michael D. Cole
Keyword(s):  
Breast Cancer ◽  
Epithelial Cells ◽  
Target Genes ◽  
Mammary Epithelial Cells ◽  
Tumor Formation ◽  
Mammary Epithelial ◽  
Breast Cancer Cell Lines ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial ◽  
Wnt Inhibitors

ABSTRACT c-myc is frequently amplified in breast cancer; however, the mechanism of myc-induced mammary epithelial cell transformation has not been defined. We show that c-Myc induces a profound morphological transformation in human mammary epithelial cells and anchorage-independent growth. c-Myc suppresses the Wnt inhibitors DKK1 and SFRP1, and derepression of DKK1 or SFRP1 reduces Myc-dependent transforming activity. Myc-dependent repression of DKK1 and SFRP1 is accompanied by Wnt target gene activation and endogenous T-cell factor activity. Myc-induced mouse mammary tumors have repressed SFRP1 and increased expression of Wnt target genes. DKK1 and SFRP1 inhibit the transformed phenotype of breast cancer cell lines, and DKK1 inhibits tumor formation. We propose a positive feedback loop for activation of the c-myc and Wnt pathways in breast cancer.

scholarly journals Viral oncogenes accelerate conversion to immortality of cultured conditionally immortal human mammary epithelial cells

Oncogene ◽  
1999 ◽  
Vol 18 (13) ◽  
pp. 2169-2180 ◽  
Author(s):  
James Garbe ◽  
Michelle Wong ◽  
Don Wigington ◽  
Paul Yaswen ◽  
Martha R Stampfer
Keyword(s):  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Human Mammary Epithelial Cells ◽  
Viral Oncogenes ◽  
Human Mammary Epithelial
Sign in / Sign up

Export Citation Format

Share Document