Transforming growth factor-β1 stimulates proliferation of Morris hepatoma cells in serum-free soft agar culture system supplemented with EGF and insulin

1990 ◽  
Vol 54 (1-2) ◽  
pp. 51-56 ◽  
Author(s):  
K. Guzik ◽  
A. Klein
Keyword(s):  
Growth Factor ◽  
Culture System ◽  
Transforming Growth Factor ◽  
Soft Agar ◽  
Transforming Growth Factor Β1 ◽  
Hepatoma Cells ◽  
Agar Culture ◽  
Serum Free ◽  
Morris Hepatoma

Transforming growth factor-β1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells

2005 ◽  
Vol 220 (1) ◽  
pp. 95-99 ◽  
Author(s):  
Hiroyuki Nakamura ◽  
Mutsuko Mukai ◽  
Keiko Komatsu ◽  
Miki Tanaka-Okamoto ◽  
Yu Itoh ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Hepatoma Cells ◽  
Ascites Hepatoma ◽  
Rat Ascites Hepatoma

scholarly journals S-adenosylmethionine decarboxylase gene expression in rat hepatoma cells: regulation by insulin and by inhibition of protein synthesis

1996 ◽  
Vol 316 (1) ◽  
pp. 273-277 ◽  
Author(s):  
Tiina SOININEN ◽  
Marja K. LIISANANTTI ◽  
Antti E. I. PAJUNEN
Keyword(s):  
Growth Factor ◽  
Insulin Treatment ◽  
Transforming Growth Factor ◽  
Insulin Response ◽  
Transforming Growth Factor Β1 ◽  
Hepatoma Cells ◽  
Adenosylmethionine Decarboxylase ◽  
The Stability ◽  
Rat Hepatoma ◽  
Rat Hepatoma Cells

We have investigated expression of the S-adenosylmethionine decarboxylase (AdoMetDC) gene in H4-II-E rat hepatoma cells treated with growth factors (epidermal growth factor and transforming growth factor β1) and inducers (cAMP and insulin). Treatment with insulin caused a marked increase in both RNA level and enzyme activity. The stability of AdoMetDC mRNA was not altered by insulin treatment: the accumulation of mRNA in hepatoma cells therefore seems to be due to an increase in the transcription rate. Cycloheximide was found to be a strong inducer of AdoMetDC mRNA transcription and the effects of insulin and cycloheximide were additive, suggesting that they increase expression by separate mechanisms. Chloramphenicol acetyltransferase assays in rat hepatoma cells using 5´ flanking regions of different lengths revealed that the promoter region extending 337 bp upstream from the transcription start site contains elements involved in insulin response.

scholarly journals Characterization of the Transforming Growth Factor-β1-induced Apoptotic Transcriptome in FaO Hepatoma Cells

2002 ◽  
Vol 278 (8) ◽  
pp. 5920-5928 ◽  
Author(s):  
Beth Coyle ◽  
Caroline Freathy ◽  
Timothy W. Gant ◽  
Ruth A. Roberts ◽  
Kelvin Cain
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Hepatoma Cells
Sign in / Sign up

Export Citation Format

Share Document