Co-Localization of substance P- and phenylethanolamine-N-methyltransferase-like immunoreactivity in neurons of ventrolateral medulla that project to the spinal cord: Potential role in control of vasomotor tone

1985 ◽  
Vol 55 (3) ◽  
pp. 255-260 ◽  
Author(s):  
Robin G. Lorenz ◽  
Clifford B. Saper ◽  
Dona L. Wong ◽  
Roland D. Ciaranello ◽  
Arthur D. Loewy
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Potential Role ◽  
Ventrolateral Medulla ◽  
Vasomotor Tone ◽  
Spinal Cord Potential ◽  
Cord Potential

scholarly journals Occurrence of Volcanogenic Inorganic Mercury in Wild Mice Spinal Cord: Potential Health Implications

2021 ◽  
Author(s):  
A. Navarro-Sempere ◽  
M. García ◽  
A. S. Rodrigues ◽  
P. V. Garcia ◽  
R. Camarinho ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Inorganic Mercury ◽  
Elemental Mercury ◽  
Potential Health ◽  
Wild Mice ◽  
Gaseous Elemental Mercury ◽  
Lumbar Level ◽  
Quantification Analysis ◽  
Spinal Cord Potential ◽  
Cord Potential

AbstractMercury accumulation has been proposed as a toxic factor that causes neurodegenerative diseases. However, the hazardous health effects of gaseous elemental mercury exposure on the spinal cord in volcanic areas have not been reported previously in the literature. To evaluate the presence of volcanogenic inorganic mercury in the spinal cord, a study was carried out in São Miguel island (Azores, Portugal) by comparing the spinal cord of mice exposed chronically to an active volcanic environment (Furnas village) with individuals not exposed (Rabo de Peixe village), through the autometallographic silver enhancement histochemical method. Moreover, a morphometric and quantification analysis of the axons was carried out. Results exhibited mercury deposits at the lumbar level of the spinal cord in the specimens captured at the site with volcanic activity (Furnas village). A decrease in axon calibre and axonal atrophy was also observed in these specimens. Given that these are relevant hallmarks in the neurodegenerative pathologies, our results highlight the importance of the surveillance of the health of populations chronically exposed to active volcanic environments.

scholarly journals Thoracic evoked spinal cord potential by stimulation of the intercostal nerve.

1990 ◽  
Vol 38 (3) ◽  
pp. 1092-1094
Author(s):  
Kazuo Kaneko ◽  
Shinya Kawai ◽  
Kazuo Nakata ◽  
Yasunori Fuchigami ◽  
Fujio Sasabe ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Intercostal Nerve ◽  
Spinal Cord Potential ◽  
Cord Potential ◽  
Stimulation Of

Endothelin receptor expression in the normal and injured spinal cord: potential involvement in injury-induced ischemia and gliosis

2003 ◽  
Vol 180 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Christopher M Peters ◽  
Scott D Rogers ◽  
James D Pomonis ◽  
Greg F Egnazyck ◽  
Cathy P Keyser ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Receptor Expression ◽  
Endothelin Receptor ◽  
Injured Spinal Cord ◽  
Spinal Cord Potential ◽  
Cord Potential

scholarly journals Feed-Forward Inhibition: A Novel Cellular Mechanism for the Analgesic Effect of Substance P

2005 ◽  
Vol 1 ◽  
pp. 1744-8069-1-34 ◽  
Author(s):  
Long-Jun Wu ◽  
Hui Xu ◽  
Shanelle W Ko ◽  
Megumu Yoshimura ◽  
Min Zhuo
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Potential Role ◽  
Feed Forward ◽  
Direct Excitation ◽  
Temporal Phase ◽  
Pain Transmission ◽  
Afferent Fibers ◽  
Primary Afferent Fibers ◽  
Feed Forward Inhibition

Substance P (SP) is a neuropeptide well known for its contribution to pain transmission in the spinal cord, however, less is known about the possible modulatory effects of SP. A new study by Gu and colleagues, published in Molecular Pain (2005, 1:20), describes its potential role in feed-forward inhibition in lamina V of the dorsal horn of the spinal cord. This inhibition seems to function through a direct excitation of GABAergic interneurons by substance P released from primary afferent fibers and has a distinct temporal phase of action from the well-described glutamate-dependent feed-forward inhibition. It is believed that through this inhibition, substance P can balance nociceptive output from the spinal cord.

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