No changes in central quinolinic acid levels in Alzheimer's disease

1989 ◽  
Vol 105 (1-2) ◽  
pp. 233-238 ◽  
Author(s):  
M.M. Mourdian ◽  
M.P. Heyes ◽  
J.-B. Pan ◽  
I.J.E. Heuser ◽  
S.P. Markey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quinolinic Acid

QUINOLINIC ACID IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE

2003 ◽  
pp. 167-176 ◽  
Author(s):  
Gilles J. Guillemin ◽  
Kieran R. Williams ◽  
Danielle G. Smith ◽  
George A. Smythe ◽  
Juliana Croitoru-Lamoury ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quinolinic Acid

Mass spectrometric detection of quinolinic acid in microdissected Alzheimer's disease plaques

2007 ◽  
Vol 1304 ◽  
pp. 404-408 ◽  
Author(s):  
Gilles J. Guillemin ◽  
Bruce J. Brew ◽  
Claire E. Noonan ◽  
Toby G. Knight ◽  
George A. Smythe ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quinolinic Acid ◽  
Mass Spectrometric ◽  
Mass Spectrometric Detection

Synergistic Toxicity of the Neurometabolites Quinolinic Acid and Homocysteine in Cortical Neurons and Astrocytes: Implications in Alzheimer’s Disease

2017 ◽  
Vol 34 (1) ◽  
pp. 147-163 ◽  
Author(s):  
Paula Pierozan ◽  
Helena Biasibetti-Brendler ◽  
Felipe Schmitz ◽  
Fernanda Ferreira ◽  
Carlos Alexandre Netto ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quinolinic Acid ◽  
Cortical Neurons ◽  
Synergistic Toxicity

scholarly journals Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
S. Duleu ◽  
A. Mangas ◽  
F. Sevin ◽  
B. Veyret ◽  
A. Bessede ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chronic Diseases ◽  
Quinolinic Acid ◽  
Kynurenic Acid ◽  
Tryptophan Hydroxylase ◽  
Elisa Method ◽  
Tryptophan Metabolites ◽  
Circulating Antibodies ◽  
Tryptophan Derivatives

In Alzheimer's disease, indoleamine 2,3-dioxygenase and tryptophan hydroxylase are known to induce an overproduction of neurotoxic compounds, such as quinolinic acid and 3-hydroxykynurenine from the former, and 5-hydroxytryptophol and 5-methoxytryptophol from the latter. Other compounds, such as kynurenic acid, serotonin, and melatonin are produced via the same pathways. An improved ELISA method identified circulating antibodies directed against these compounds, linked to proteins, as previously described for other chronic diseases. This describes how only the A isotype of circulating immunoglobulins recognized a pattern of conjugated tryptophan metabolites in the sera of Alzheimer patients. These data indirectly confirmed the involvement of tryptophan derivatives in the pathogenic processes of Alzheimer's disease. Further studies are required to evaluate the relevance of these antibody patterns in monitoring this disease.

P4-065: Beta-amyloid production from reactive astrocytes induced by endogenous neurotoxin quinolinic acid: A new aspect of Alzheimer's disease

2012 ◽  
Vol 8 (4S_Part_18) ◽  
pp. P656-P656
Author(s):  
Alato Okuno ◽  
Tatsuya Yoshimi ◽  
Kayo Adachi ◽  
Ryuta Mikawa ◽  
Akiko Takayanagi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quinolinic Acid ◽  
Beta Amyloid ◽  
Reactive Astrocytes

Indoleamine 2,3 dioxygenase and quinolinic acid Immunoreactivity in Alzheimer's disease hippocampus

2005 ◽  
Vol 31 (4) ◽  
pp. 395-404 ◽  
Author(s):  
G. J. Guillemin ◽  
B. J. Brew ◽  
C. E. Noonan ◽  
O. Takikawa ◽  
K. M. Cullen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quinolinic Acid ◽  
Indoleamine 2,3 Dioxygenase
Sign in / Sign up

Export Citation Format

Share Document