Mass spectrometric detection of quinolinic acid in microdissected Alzheimer's disease plaques

2007 ◽  
Vol 1304 ◽  
pp. 404-408 ◽  
Author(s):  
Gilles J. Guillemin ◽  
Bruce J. Brew ◽  
Claire E. Noonan ◽  
Toby G. Knight ◽  
George A. Smythe ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quinolinic Acid ◽  
Mass Spectrometric ◽  
Mass Spectrometric Detection

QUINOLINIC ACID IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE

2003 ◽  
pp. 167-176 ◽  
Author(s):  
Gilles J. Guillemin ◽  
Kieran R. Williams ◽  
Danielle G. Smith ◽  
George A. Smythe ◽  
Juliana Croitoru-Lamoury ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quinolinic Acid

Mass Spectrometric Characterization of Amyloid-β Species in the 7PA2 Cell Model of Alzheimer's Disease

2012 ◽  
Vol 33 (1) ◽  
pp. 85-93 ◽  
Author(s):  
Erik Portelius ◽  
Maria Olsson ◽  
Gunnar Brinkmalm ◽  
Ulla Rüetschi ◽  
Niklas Mattsson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Model ◽  
Amyloid Β ◽  
Mass Spectrometric ◽  
Model Of Alzheimer’S Disease ◽  
7Pa2 Cell

Synergistic Toxicity of the Neurometabolites Quinolinic Acid and Homocysteine in Cortical Neurons and Astrocytes: Implications in Alzheimer’s Disease

2017 ◽  
Vol 34 (1) ◽  
pp. 147-163 ◽  
Author(s):  
Paula Pierozan ◽  
Helena Biasibetti-Brendler ◽  
Felipe Schmitz ◽  
Fernanda Ferreira ◽  
Carlos Alexandre Netto ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quinolinic Acid ◽  
Cortical Neurons ◽  
Synergistic Toxicity

scholarly journals Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
S. Duleu ◽  
A. Mangas ◽  
F. Sevin ◽  
B. Veyret ◽  
A. Bessede ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chronic Diseases ◽  
Quinolinic Acid ◽  
Kynurenic Acid ◽  
Tryptophan Hydroxylase ◽  
Elisa Method ◽  
Tryptophan Metabolites ◽  
Circulating Antibodies ◽  
Tryptophan Derivatives

In Alzheimer's disease, indoleamine 2,3-dioxygenase and tryptophan hydroxylase are known to induce an overproduction of neurotoxic compounds, such as quinolinic acid and 3-hydroxykynurenine from the former, and 5-hydroxytryptophol and 5-methoxytryptophol from the latter. Other compounds, such as kynurenic acid, serotonin, and melatonin are produced via the same pathways. An improved ELISA method identified circulating antibodies directed against these compounds, linked to proteins, as previously described for other chronic diseases. This describes how only the A isotype of circulating immunoglobulins recognized a pattern of conjugated tryptophan metabolites in the sera of Alzheimer patients. These data indirectly confirmed the involvement of tryptophan derivatives in the pathogenic processes of Alzheimer's disease. Further studies are required to evaluate the relevance of these antibody patterns in monitoring this disease.

No changes in central quinolinic acid levels in Alzheimer's disease

1989 ◽  
Vol 105 (1-2) ◽  
pp. 233-238 ◽  
Author(s):  
M.M. Mourdian ◽  
M.P. Heyes ◽  
J.-B. Pan ◽  
I.J.E. Heuser ◽  
S.P. Markey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quinolinic Acid

scholarly journals Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.

1992 ◽  
Vol 267 (24) ◽  
pp. 17047-17054 ◽  
Author(s):  
M Hasegawa ◽  
M Morishima-Kawashima ◽  
K Takio ◽  
M Suzuki ◽  
K Titani ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Protein Sequence ◽  
Mass Spectrometric

scholarly journals Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease

2010 ◽  
Vol 120 (2) ◽  
pp. 185-193 ◽  
Author(s):  
Erik Portelius ◽  
Nenad Bogdanovic ◽  
Mikael K. Gustavsson ◽  
Inga Volkmann ◽  
Gunnar Brinkmalm ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Mass Spectrometric ◽  
Sporadic Alzheimer’S Disease
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