Inhibition of enzymic reactions by transition state analogs: An approach for drug design

General Pharmacology The Vascular System ◽

10.1016/0306-3623(81)90002-1 ◽

1981 ◽

Vol 12 (3) ◽

pp. 129-138 ◽

Author(s):

T.T. Ngo ◽

G. Tunnicliff

Keyword(s):

Drug Design ◽

Transition State ◽

Transition State Analogs

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Faculty Opinions recommendation of Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1126855.583957 ◽

2008 ◽

Author(s):

Arieh Warshel

Keyword(s):

Transition State ◽

Magnesium Fluoride ◽

Phosphoryl Transfer ◽

Transition State Analogs ◽

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Transition state analogs for thiamin pyrophosphate-dependent enzymes.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)33570-6 ◽

1976 ◽

Vol 251 (9) ◽

pp. 2863-2866 ◽

Author(s):

J A Gutowski ◽

G E Lienhard

Keyword(s):

Transition State ◽

Transition State Analogs ◽

Thiamin Pyrophosphate

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Potential transition-state analogs for glycosyltransferases. Design and DFT calculations of conformational behavior

Carbohydrate Research ◽

10.1016/j.carres.2005.01.041 ◽

2005 ◽

Vol 340 (5) ◽

pp. 1051-1057 ◽

Author(s):

Michal Raab ◽

Stanislav Kozmon ◽

Igor Tvaroška

Keyword(s):

Dft Calculations ◽

Transition State ◽

Conformational Behavior ◽

Transition State Analogs

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Quantum chemical analysis of the interactions of transition state analogs with leucine aminopeptidase

International Journal of Quantum Chemistry ◽

10.1002/qua.1335 ◽

2001 ◽

Vol 84 (2) ◽

pp. 302-310 ◽

Author(s):

J. Grembecka ◽

W. A. Sokalski ◽

P. Kafarski

Keyword(s):

Chemical Analysis ◽

Transition State ◽

Quantum Chemical ◽

Leucine Aminopeptidase ◽

Quantum Chemical Analysis ◽

Transition State Analogs

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Design and Synthesis of Transition State Analogs for Induction of Hydride Transfer Catalytic Antibodies

The Journal of Organic Chemistry ◽

10.1021/jo962179v ◽

1997 ◽

Vol 62 (10) ◽

pp. 3220-3229 ◽

Author(s):

Josef Schröer ◽

Michel Sanner ◽

Jean-Louis Reymond

Keyword(s):

Transition State ◽

Hydride Transfer ◽

Catalytic Antibodies ◽

Design And Synthesis ◽

Transition State Analogs

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Transition state analogs of 5′-methylthioadenosine nucleosidase disrupt quorum sensing

Nature Chemical Biology ◽

10.1038/nchembio.153 ◽

2009 ◽

Vol 5 (4) ◽

pp. 251-257 ◽

Author(s):

Jemy A Gutierrez ◽

Tamara Crowder ◽

Agnes Rinaldo-Matthis ◽

Meng-Chiao Ho ◽

Steven C Almo ◽

...

Keyword(s):

Quorum Sensing ◽

Transition State ◽

Transition State Analogs

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TRANSITION STATE ANALOGS AS ANTIMETABOLITES

Antimetabolites in Biochemistry, Biology and Medicine ◽

10.1016/b978-0-08-024384-9.50016-6 ◽

1979 ◽

pp. 151-160 ◽

Author(s):

Richard Wolfenden

Keyword(s):

Transition State ◽

Transition State Analogs

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Crystallographic structural analysis of phosphoramidates as inhibitors and transition-state analogs of thermolysin

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1986.tb09664.x ◽

1986 ◽

Vol 157 (2) ◽

pp. 261-268 ◽

Author(s):

Dale E. TRONRUD ◽

Arthur F. MONZINGO ◽

Brian W. MATTHEWS

Keyword(s):

Structural Analysis ◽

Transition State ◽

Transition State Analogs

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The derivation of a potential transition state for the reduction reaction catalysed by 17β-hydroxysteroid dehydrogenase—an approximate representation of its active site for use in drug design and discovery

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2004.03.190 ◽

2004 ◽

Vol 318 (1) ◽

pp. 131-134 ◽

Author(s):

Caroline P Owen ◽

Sabbir Ahmed

Keyword(s):

Drug Design ◽

Transition State ◽

Active Site ◽

Hydroxysteroid Dehydrogenase ◽

Reduction Reaction ◽

Approximate Representation

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Chapter 23. Transition State Analogs as Enzyme Inhibitors

Annual Reports in Medicinal Chemistry ◽

10.1016/s0065-7743(08)60818-0 ◽

1972 ◽

pp. 249-258 ◽

Author(s):

G.E. Lienhard

Keyword(s):

Transition State ◽

Enzyme Inhibitors ◽

Transition State Analogs

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