Relationship between dopamine release in the rat nucleus accumbens and the discharge activity of dopaminergic neurons during local in vivo application of amino acids in the ventral tegmental area

Neuroscience ◽  
1992 ◽  
Vol 49 (1) ◽  
pp. 63-72 ◽  
Author(s):  
M.F. Suaud-Chagny ◽  
K. Chergui ◽  
G. Chouvet ◽  
F. Gonon
Keyword(s):  
Amino Acids ◽  
Nucleus Accumbens ◽  
Ventral Tegmental Area ◽  
Dopaminergic Neurons ◽  
Dopamine Release ◽  
Discharge Activity ◽  
Ventral Tegmental ◽  
Rat Nucleus Accumbens

Eating and drinking cause increased dopamine release in the nucleus accumbens and ventral tegmental area in the rat: Measurement by in vivo microdialysis

1992 ◽  
Vol 139 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Masami Yoshida ◽  
Hideyasu Yokoo ◽  
Katsuhiro Mizoguchi ◽  
Hiroshi Kawahara ◽  
Akira Tsuda ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Ventral Tegmental Area ◽  
Dopamine Release ◽  
In Vivo Microdialysis ◽  
Ventral Tegmental

scholarly journals Programming of Dopaminergic Neurons by Neonatal Sex Hormone Exposure: Effects on Dopamine Content and Tyrosine Hydroxylase Expression in Adult Male Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Pedro Espinosa ◽  
Roxana A. Silva ◽  
Nicole K. Sanguinetti ◽  
Francisca C. Venegas ◽  
Raul Riquelme ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Tyrosine Hydroxylase ◽  
Substantia Nigra ◽  
Ventral Tegmental Area ◽  
Dopaminergic Neurons ◽  
Dopamine Release ◽  
Male Rats ◽  
Midbrain Dopaminergic Neurons ◽  
Dopamine Content ◽  
Ventral Tegmental

We sought to determine the long-term changes produced by neonatal sex hormone administration on the functioning of midbrain dopaminergic neurons in adult male rats. Sprague-Dawley rats were injected subcutaneously at postnatal day 1 and were assigned to the following experimental groups: TP (testosterone propionate of 1.0 mg/50 μL); DHT (dihydrotestosterone of 1.0 mg/50 μL); EV (estradiol valerate of 0.1 mg/50 μL); and control (sesame oil of 50 μL). At postnatal day 60, neurochemical studies were performed to determine dopamine content in substantia nigra-ventral tegmental area and dopamine release in nucleus accumbens. Molecular (mRNA expression of tyrosine hydroxylase) and cellular (tyrosine hydroxylase immunoreactivity) studies were also performed. We found increased dopamine content in substantia nigra-ventral tegmental area of TP and EV rats, in addition to increased dopamine release in nucleus accumbens. However, neonatal exposure to DHT, a nonaromatizable androgen, did not affect midbrain dopaminergic neurons. Correspondingly, compared to control rats, levels of tyrosine hydroxylase mRNA and protein were significantly increased in TP and EV rats but not in DHT rats, as determined by qPCR and immunohistochemistry, respectively. Our results suggest an estrogenic mechanism involving increased tyrosine hydroxylase expression, either by direct estrogenic action or by aromatization of testosterone to estradiol in substantia nigra-ventral tegmental area.

scholarly journals Insulin in the ventral tegmental area reduces cocaine‐evoked dopamine in the nucleus accumbens in vivo

2018 ◽  
Vol 50 (3) ◽  
pp. 2146-2155 ◽  
Author(s):  
Lindsay Naef ◽  
Lauren Seabrook ◽  
Jeff Hsiao ◽  
Calvin Li ◽  
Stephanie L. Borgland
Keyword(s):  
Nucleus Accumbens ◽  
Ventral Tegmental Area ◽  
Ventral Tegmental
Sign in / Sign up

Export Citation Format

Share Document