Does oxygen free radical increased formation explain long term complications of diabetes mellitus?

1989 ◽  
Vol 29 (1) ◽  
pp. 47-50 ◽  
Author(s):  
P. Gillery ◽  
J.-C. Monboisse ◽  
F.-X. Maquart ◽  
J.-P. Borel
Keyword(s):  
Diabetes Mellitus ◽  
Free Radical ◽  
Oxygen Free Radical ◽  
Complications Of Diabetes

scholarly journals Long Term Complications of Diabetes – A Review

2014 ◽  
Vol 21 (4) ◽  
pp. 347-355
Author(s):  
Ionuţ Vlad ◽  
Dana Sonia Oieru ◽  
Amorin Remus Popa ◽  
Mihaela Zaharia
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Manifestations ◽  
Prevention Strategies ◽  
Chronic Complications ◽  
Complications Of Diabetes ◽  
Full Picture

Abstract It is estimated that subclinical DM (diabetes mellitus) has the onset about 10 years before the appearance of actual clinical manifestations, leading to uncontrolled chronic complications. Many trials have pursued the onset and evolution of the DM chronic complications in order to obtain a full picture that allows the development of prevention strategies, treatments and DM costs reduction.

Complications of Diabetes Mellitus

2019 ◽  
Author(s):  
Samuel Dagogo-Jack
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Neuropathy ◽  
Key Words ◽  
Diabetic Patients ◽  
Chronic Complications ◽  
Complications Of Diabetes ◽  
Vessel Disease ◽  
Key Words Hyperglycemia ◽  
Large Vessel Disease

The long-term complications of diabetes mellitus include those attributable to hyperglycemia-mediated small vessel (microvascular)and neuropathic complications and syndromes resulting from multifactorial large vessel disease (macrovascular complications). Diabetic patients with evidence of chronic complications are best managed in consultation with appropriate specialists. The microvascular and neuropathic complications, which are specifically related to hyperglycemia, include retinopathy, nephropathy, and diabetic neuropathy. This review contains 8 figures, 9 tables, and 83 references. Key Words: Hyperglycemia, hypoglycemia, macrovascular, microvascular, neuropathic

Complications of Diabetes Mellitus

2019 ◽  
Author(s):  
Samuel Dagogo-Jack
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Neuropathy ◽  
Key Words ◽  
Diabetic Patients ◽  
Chronic Complications ◽  
Complications Of Diabetes ◽  
Vessel Disease ◽  
Key Words Hyperglycemia ◽  
Large Vessel Disease

The long-term complications of diabetes mellitus include those attributable to hyperglycemia-mediated small vessel (microvascular)and neuropathic complications and syndromes resulting from multifactorial large vessel disease (macrovascular complications). Diabetic patients with evidence of chronic complications are best managed in consultation with appropriate specialists. The microvascular and neuropathic complications, which are specifically related to hyperglycemia, include retinopathy, nephropathy, and diabetic neuropathy. This review contains 8 figures, 9 tables, and 83 references. Key Words: Hyperglycemia, hypoglycemia, macrovascular, microvascular, neuropathic

scholarly journals Az oxidatív stressz szerepe a diabeteses neuropathia kialakulásában

2016 ◽  
Vol 157 (49) ◽  
pp. 1939-1946 ◽  
Author(s):  
Ferenc Sztanek ◽  
Ágnes Molnárné Molnár ◽  
Zoltán Balogh
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Diabetic Neuropathy ◽  
Microvascular Complications ◽  
Advanced Glycation ◽  
Complications Of Diabetes ◽  
Kinase C ◽  
Glycation End Products ◽  
Comparative Trials

Diabetic neuropathy may be one of the most common and severe complications of diabetes mellitus. Oxidative stress plays a pivotal role in the development of microvascular complications of diabetes. The majority of related pathways like polyol and hexosamine, advanced glycation end products, poly-ADP-ribose polymerase, and protein kinase-C all originated from initial oxidative stress. In this review, the authors present the current oxidative stress hypothesis in diabetes mellitus and summarize the pathophysiological mechanisms of diabetic neuropathy associated with increased oxidative stress. The development of modern medicines to treat diabetic neuropathy needs intensive long-term comparative trials in the future. Orv. Hetil., 2016, 157(49), 1939–1946.

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