High-performance liquid chromatographic determination of amitriptyline and its main metabolites using a silica column with reversed-phase eluent

Author(s):  
Francois Coudore ◽  
Denis Ardid ◽  
Alain Eschalier ◽  
Jeannine Lavarenne ◽  
Joseph Fialip
1980 ◽  
Vol 63 (5) ◽  
pp. 988-991
Author(s):  
Graeme L Blackman ◽  
Ah Chai Ho ◽  
Alex Jozsa ◽  
John D Kelly

Abstract A high performance liquid chromatographic (HPLC) technique is described for the determination of residue levels of the anthelmintic drug phenothiazine in sheep tissues. Phenothiazine was administered to sheep which were slaughtered after withholding periods of 24, 48, and 72 h. Residues of phenothiazine were then extracted from tissue samples by homogenization in methanol. The HPLC analysis of the extracts involved separation on a 10 μm silica column using a mobile phase of 0.3% n-propanol in cyclohexane. The lower limit of detection by ultraviolet absorption at 254 nm was 0.05 ppm


2001 ◽  
Vol 24 (15) ◽  
pp. 2315-2324 ◽  
Author(s):  
Rolando González-Hernández ◽  
Lauro Nuevas-Paz ◽  
Laritza Soto-Mulet ◽  
Miguel López-López ◽  
Joseph Hoogmartens

Sign in / Sign up

Export Citation Format

Share Document