scholarly journals Alterations in endocardial vascular resistance after reperfusion in a low flow, high demand model of ischemia: effects of dipyridamole and WEB-2086, a platelet-activating factor antagonist

1990 ◽  
Vol 16 (7) ◽  
pp. 1750-1759 ◽  
Author(s):  
Erwin Schröder ◽  
Hubert Pouleur ◽  
Henri Van Mechelen ◽  
André Keyeux ◽  
Juan Raigoso ◽  
...  
Keyword(s):  
Vascular Resistance ◽  
Platelet Activating Factor ◽  
Low Flow ◽  
Demand Model ◽  
High Demand ◽  
Factor Antagonist ◽  
Web 2086

The effect of the orally active platelet-activating factor antagonist WEB 2086 in the treatment of asthma.

1994 ◽  
Vol 149 (5) ◽  
pp. 1142-1148 ◽  
Author(s):  
D P Spence ◽  
S L Johnston ◽  
P M Calverley ◽  
P Dhillon ◽  
C Higgins ◽  
...  
Keyword(s):  
Platelet Activating Factor ◽  
Orally Active ◽  
Factor Antagonist ◽  
Web 2086

Effect of PAF receptor antagonism on cardiopulmonary alterations during coinfusion of TNF-alpha and IL-1 alpha in pigs

1993 ◽  
Vol 264 (2) ◽  
pp. L175-L182 ◽  
Author(s):  
K. T. Kruse-Elliott ◽  
M. V. Pino ◽  
N. C. Olson
Keyword(s):  
Vascular Resistance ◽  
Interleukin 1 ◽  
Plasma Concentrations ◽  
Platelet Activating Factor ◽  
Physiological Role ◽  
Systemic Hypertension ◽  
Tnf Alpha ◽  
Pulmonary Hemodynamics ◽  
Paf Receptor ◽  
Web 2086

We examined the possibility that platelet-activating factor (PAF) might be a mediator of cardiopulmonary alterations induced by a 6-h coinfusion of human recombinant tumor necrosis factor (TNF-alpha) and interleukin-1 alpha (IL-1 alpha) in anesthetized pigs. Our hypothesis was tested by pretreating TNF-alpha + IL-1 alpha-infused pigs with WEB 2086 (3 mg/kg from -0.5 to 0 h + 0.75 mg.kg-1.h-1 from 0–6 h), a specific PAF receptor antagonist. Each cytokine was infused intravenously at 0.5 microgram/kg from 0-0.5 h + 5 ng.kg-1.min-1 from 0.5-6 h. WEB 2086 attenuated the early (0.25 h) cytokine-induced increases in mean pulmonary arterial pressure and pulmonary vascular resistance and blocked or markedly attenuated the later occurring (4–6 h) systemic hypertension and increased systemic vascular resistance. WEB 2086 lessened the severity of TNF-alpha + IL-1 alpha-induced hemoconcentration and airway constriction, but did not modify leukopenia, granulocytopenia, or the cytokine-induced increases in plasma concentrations of thromboxane B2, prostaglandin F2 alpha, and 6-ketoprostaglandin F1 alpha. Microscopically, WEB 2086 did not modify the increased number of granulocytes present in lung tissue derived from pigs infused with TNF-alpha + IL-1 alpha. We conclude that PAF occupies a physiological role in modulating TNF-alpha + IL-1 alpha-induced hemoconcentration, the early changes in pulmonary hemodynamics, and the later alterations in systemic hemodynamics.

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