Effects of combined pre- and postnatal ethanol exposure (three trimester equivalency) on glial cell development in rat optic nerve

1992 ◽  
Vol 10 (3) ◽  
pp. 197-206 ◽  
Author(s):  
D.E. Phillips ◽  
S.K. Krueger
Keyword(s):  
Optic Nerve ◽  
Glial Cell ◽  
Cell Development ◽  
Ethanol Exposure

Glial cell development in the rat optic nerve

1984 ◽  
Vol 7 (12) ◽  
pp. 469-472 ◽  
Author(s):  
Martin C. Raff ◽  
Robert H. Miller
Keyword(s):  
Optic Nerve ◽  
Glial Cell ◽  
Cell Development

Characterization of TROY-expressing cells in the developing and postnatal CNS: the possible role in neuronal and glial cell development

2006 ◽  
Vol 23 (12) ◽  
pp. 3149-3160 ◽  
Author(s):  
Tomoko Hisaoka ◽  
Yoshihiro Morikawa ◽  
Tadasuke Komori ◽  
Takuya Sugiyama ◽  
Toshio Kitamura ◽  
...  
Keyword(s):  
Glial Cell ◽  
Cell Development

Glial cell responses in the retina following transection of the optic nerve

1992 ◽  
Vol 40 (1) ◽  
pp. 134
Author(s):  
Jutta Schnitzer ◽  
Jürgen Scherer
Keyword(s):  
Optic Nerve ◽  
Glial Cell ◽  
Cell Responses

scholarly journals Advances in myelinating glial cell development

2017 ◽  
Vol 42 ◽  
pp. 53-60 ◽  
Author(s):  
Amy L Herbert ◽  
Kelly R Monk
Keyword(s):  
Glial Cell ◽  
Cell Development

scholarly journals Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development in the Drosophila larval brain

2020 ◽  
Vol 133 (19) ◽  
pp. jcs250837
Author(s):  
Majd M. Ariss ◽  
Alexander R. Terry ◽  
Abul B. M. M. K. Islam ◽  
Nissim Hay ◽  
Maxim V. Frolov
Keyword(s):  
Cell Proliferation ◽  
Tyrosine Kinase ◽  
Glial Cell ◽  
Receptor Tyrosine Kinase ◽  
Cell Development ◽  
Negative Regulator ◽  
Larval Brain ◽  
Adhesion Protein ◽  
Type Composition ◽  
Signaling Activation

ABSTRACTThe receptor tyrosine kinase (RTK) pathway plays an essential role in development and disease by controlling cell proliferation and differentiation. Here, we profile the Drosophila larval brain by single-cell RNA-sequencing and identify Amalgam (Ama), which encodes a cell adhesion protein of the immunoglobulin IgLON family, as regulating the RTK pathway activity during glial cell development. Depletion of Ama reduces cell proliferation, affects glial cell type composition and disrupts the blood–brain barrier (BBB), which leads to hemocyte infiltration and neuronal death. We show that Ama depletion lowers RTK activity by upregulating Sprouty (Sty), a negative regulator of the RTK pathway. Knockdown of Ama blocks oncogenic RTK signaling activation in the Drosophila glioma model and halts malignant transformation. Finally, knockdown of a human ortholog of Ama, LSAMP, results in upregulation of SPROUTY2 in glioblastoma cell lines, suggesting that the relationship between Ama and Sty is conserved.

scholarly journals MAPK signaling during Müller glial cell development in retina explant cultures

2010 ◽  
Vol 3 (4) ◽  
pp. 129-133 ◽  
Author(s):  
Samuel Shao-Min Zhang ◽  
Hong Li ◽  
Ping Huang ◽  
Lucy Xi Lou ◽  
Xin-Yuan Fu ◽  
...  
Keyword(s):  
Glial Cell ◽  
Mapk Signaling ◽  
Cell Development ◽  
Müller Glial Cell ◽  
Explant Cultures
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